Effects of Acute Sleep Deprivation on Health
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age20-45
SponsorNational Taiwan Normal University
About this trial
This study will investigate whether various types of regular exercise can provide protective effects against metabolic abnormalities induced by sleep restriction. It will examine responses related to metabolic health, cognitive function, energy expenditure, subjective feelings, and human behaviors, including physical activity and energy intake.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age between 20-45 years.
Body Mass Index (BMI) between 18.5-27 kg/m².
No sleep-related medical conditions and good sleep quality, defined as a Pittsburgh Sleep Quality Index (PSQI) score ≤ 5.
Usual bedtime between 22:00-01:00, wake-up time between 06:00-09:00, with an average sleep duration of 7 to 9 hours; chronotype classified as "definitely not evening type" (score ≥ 42 on the Morningness-Eveningness Questionnaire), and no changes in sleep patterns over the past 3 months.
Disqualifiers
Special diets (e.g., intermittent fasting, ketogenic diet)
Recent injuries or contraindications to intense exercise.
Trial design
Design model
Crossover
Treatments tested in this trial
Normal sleep
BehavioralParticipants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00.
Partial sleep deprivation
BehavioralParticipants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00.
Treatment groups
48 Participants
are divided into 2 treatment groupsGroup A: Normal sleepExperimental treatment 1 intervention
Group B: Partial sleep deprivationExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Glycemic Control
Glucose responses during the 3-hour oral glucose tolerance test (OGTT)
Time frame
Baseline measurements and continuously at regular intervals throughout the 3-hour OGTT.2
Pulse wave velocity (PWV)
Pulse wave velocity assessments (i.e., meters per second) will be collected before and during the 3-hour oral glucose tolerance test (OGTT).
Time frame
0 (baseline), 60, 120 and 180 minutes during OGTT3
Cognitive function (Accuracy)
Accuracy (i.e., %) in computerized tests will be tested before and during the 3-hour oral glucose tolerance test (OGTT).
Time frame
0 (baseline), 90 and 180 minutes during OGTT4
Cognitive function (Reaction time)
Reaction time (i.e., milliseconds) in computerized tests will be tested before and during the 3-hour oral glucose tolerance test (OGTT).
Time frame
0 (baseline), 90 and 180 minutes during OGTTSecondary outcomes
1
Resting energy expenditure
Energy expenditure will be collected before and during the 3-hour oral glucose tolerance test (OGTT).
Time frame
0 (baseline), 60, 120 and 180 minutes during OGTT2
Carbohydrate oxidation
Carbohydrate oxidation will be collected before and during the 3-hour oral glucose tolerance test (OGTT).
Time frame
0 (baseline), 60, 120 and 180 minutes during OGTT3
Fat oxidation
Fat oxidation will be collected before and during the 3-hour oral glucose tolerance test (OGTT).
Time frame
0 (baseline), 60, 120 and 180 minutes during OGTT4
Heart rate variability
Heart rate variability will be collected before and during the 3-hour oral glucose tolerance test (OGTT).
Time frame
0 (baseline), 60, 120 and 180 minutes during OGTTLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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