Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome
ConditionDiet Intervention
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorUniversity of Missouri-Columbia
About this trial
This study is investigating the benefits of lean beef consumption on cardiometabolic health and gut microbiome.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age: 18-45 years of age
BMI: 18-35 kg/m2
Willingness to consume study foods.
Willing to comply with study protocol.
Disqualifiers
Allergies to foods provided in the study
Diabetes
Gastrointestinal disease and/or bariatric surgery
Uncontrolled hypertension and blood pressure ≥ 180/110
Trial design
Design model
Parallel
Treatments tested in this trial
Lean (≥90%) Grass-Fed Beef
Other interventionThe specified amount will be 4 oz. per day or 28 ounces per week for participants with an energy requirement of 2000 kcal.
Lean (≥90%) Grain-Fed Beef
Other interventionThe specified amount will be 4 oz. per day or 28 ounces per week for participants with an energy requirement of 2000 kcal.
Plant-Based Meat
Other interventionPlant-based meat would be macronutrient matched to the same quantities of meat prescribed for a given energy level.
Treatment groups
90 Participants
are divided into 3 treatment groupsGroup A: Lean (≥90%) Grass-Fed BeefExperimental treatment 1 intervention
Group B: Lean (≥90%) Grain-Fed BeefExperimental treatment 1 intervention
Group C: Plant-Based MeatActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
LDL-C concentrations
Lipid profile
Time frame
Baseline, week 62
Interleukin-6 concentrations
Inflammatory marker
Time frame
Baseline, week 63
Gut microbial alpha-diversity
Assessed via16S rRNA sequencing
Time frame
Baseline, week 6Secondary outcomes
1
HDL-C concentrations
Lipid profile
Time frame
Baseline, week 62
Total cholesterol concentrations
Lipid profile
Time frame
Baseline, week 63
Triglyceride concentrations
Lipid profile
Time frame
Baseline, week 64
Gut microbiome abundance
16S rRNA sequencing
Time frame
Baseline, week 6Other outcomes
1
Metabolite intensities
Untargeted and targeted metabolomics
Time frame
Baseline, week 62
Nutrient intakes
24 hours dietary recall
Time frame
Baseline, week 3, week 6Sponsors and contacts
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Source ClinicalTrials.gov