This study will examine whether light physical activity after meals can improve 24-hour glucose responses in adults with metabolic syndrome and prediabetes.
Participants will complete three experimental conditions in a randomized crossover order: prolonged sitting, 15 minutes of postprandial walking, and brief resistance exercise snacks consisting of squats and calf raises performed every 20 minutes during the postprandial period. Continuous glucose monitoring will be used to assess 24-hour glucose responses, and heart rate variability will be measured during the 2-hour postprandial period to evaluate acute autonomic responses.
The main outcome is 24-hour mean glucose derived from continuous glucose monitoring.
Adults aged 40 to 65 years
Presence of metabolic syndrome
Fasting glucose of 100 mg/dL or higher or HbA1c of 5.7% or higher
Not regularly engaged in structured exercise training, defined as less than 150 minutes per week during the past year
History of major cardiovascular, cerebrovascular, respiratory, renal, hepatic, neurological, or other severe medical conditions that may affect study participation.
Uncontrolled hypertension, defined as systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg.
Current use of medications associated with a high risk of hypoglycemia, such as insulin or sulfonylureas.
Initiation or dose change of insulin or oral glucose-lowering medications within the past 3 months.
Crossover
Postprandial walking
BehavioralParticipants will perform 15 minutes of light-to-moderate walking after consuming a standardized meal. Walking intensity will be monitored using heart rate and rating of perceived exertion.
Brief resistance exercise snacks
BehavioralParticipants will perform 3-minute bouts of body-weight resistance exercises every 20 minutes during the postprandial period after consuming a standardized meal. The exercise bouts will include squats and calf raises.
24-hour mean glucose
Mean glucose over 24 hours after each experimental condition, derived from continuous glucose monitoring.
2-hour postprandial glucose incremental area under the curve
The 2-hour postprandial glucose incremental area under the curve will be calculated from continuous glucose monitoring data after the standardized meal.
Change in RMSSD
Change in the root mean square of successive differences from the pre-meal resting baseline during the 2-hour postprandial period. RMSSD will be calculated from RR interval data collected with a chest strap heart rate monitor.
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
