About this trial
The two main groups of medicated patients with schizophrenia (SZ) are those receiving second-generation antipsychotics and those receiving first-generation antipsychotics. The purpose of this research project is to target each patient group to examine effects of rhythmic auditory stimulation (RAS) on upper-limb movements in medicated SZ patients in a 6-month follow-up period.
The main questions of this project are:
1. Does RAS reduce severity of upper-limb bradykinesia (slow movements) and dyskinesia (repetitive and involuntary movements) after intervention, at 3-month follow-up and 6-month follow-up in SZ patients receiving second-generation antipsychotics? and 2. Does RAS reduce severity of upper-limb bradykinesia and dyskinesia after intervention, at 3-month follow-up and 6-month follow-up in SZ patients receiving first-generation antipsychotics?
Researchers will compare upper-limb movement training with the aid of RAS to upper-limb movement training without the aid of RAS to see if RAS works to improve upper-limb movements in SZ patients. Participants will:
1. Undergo an interview and movement tests and fill out questionnaires before and after the movement training program and at 3-month follow-up and 6-month follow-up; and 2. Receive movement training for 40 minutes per session for a total of 21 sessions.
Eligibility criteria
Qualifiers
A diagnosis of schizophrenia or schizoaffective disorder
Between 18 to 60 years old
Keeping the same antipsychotics and the same dosage at least 4 weeks right before joining the study
A Edinburgh Handedness Inventory score of > 60
Disqualifiers
Substance abuse or drug abuse
Neurological diseases or medical conditions that affect upper-limb movements and hearing
Other psychiatric diagnoses in addition to a diagnosis of schizophrenia or schizoaffective disorder
Between 18 to 60 years old
Trial design
Treatments tested in this trial
- RAS incorporated in upper-limb movement training
- Upper-limb movement training
Treatment groups
Sponsors and collaborators
Shu-Mei Wang
Lead sponsor
National Taipei University of Nursing and Health Sciences
Sponsor institution