EFFECTS OF TWO ANESTHESİA TECHNİQUES ON INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY

ConditionsGeneral Anesthesia Cervical Plexus Block Thyroid Surgery

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-70

SponsorHarran University

About this trial

The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and amino acid metabolism in patients undergoing thyroidectomy.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

This includes patients aged 18-70 years

classified as ASA I-III

who have undergone elective thyroidectomy.

Disqualifiers

Patients who did not wish to participate in the study voluntarily

patients for whom superficial cervical block was contraindicated

pregnant and breastfeeding women

patients in ASA IV-V groups were excluded from the study.

Trial design

Design model

Parallel

Treatments tested in this trial

General Anesthesia
Procedure/Surgery
In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block. The inflammatory response is a natural response of the body's immune system to surgical trauma, and it can vary depending on the anesthetic agent used. In regulating this response, molecules such as IL-1β, TNF-α, IL-6, IL-10, and IL-40 are important indicators that determine the severity and duration of inflammation. These parameters will be examined and compared in both groups.
cervical plexus block
Procedure/Surgery
In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block.

Treatment groups

60 Participants

are divided into 2 treatment groups

Group A: GENERAL ANESTHESIAActive comparator 1 intervention

Group B: cervical plexus blockActive comparator 1 intervention

Trial outcomes

Primary outcomes

Perioperative Inflammatory Response

IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared.

Time frame

Before the procedure, and at 2 and 6 hours after the procedure.

Inflammatory Response

IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared.

Time frame

Before the procedure, and at 2 and 6 hours after the procedure.

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Harran University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: