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Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients

ConditionsMechanically Ventilated PatientsLung ComplianceAirway Clearance Impairment
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age35-55
SponsorCairo University

About this trial

The aim of the current study is to compare the effects of ventilator hyperinflation and vibrocompression on lung compliance in mechanically ventilated patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Eighty-one mechanically ventilated patients more than 48 hours up to 7 days

Their ages range from 35 to 55 years old.

Medical stability (mean arterial pressure > 60 < 110, systolic blood pressure > 80, diastolic blood pressure > 60, fraction of inspired oxygen < 60, positive end expiratory pressure (PEEP) <10)

Disqualifiers

Unstable hemodynamics

Fraction of inspired oxygen (FiO2) ≥ 0.6

PEEP ≥ 10 cmH2O

undrained pneumothorax and hemothorax or subcutaneous emphysema

Trial design

Design model

Parallel

Treatments tested in this trial

  • Ventilator Hyperinflation

    Other intervention

    In ventilator hyperinflation volume control mode, the ventilator will be set to eight breaths per minute, and the tidal volume will be increased to deliver hyperinflation breaths that are 15 ml/kg, as will be calculated using the predicted body weight. Tidal volume will be increased in 150-ml increments until a peak airway pressure of 40 cmH2O is achieved. Once this pressure is reached, eight mechanical breaths will be delivered to the patient. After this, the ventilator will be reset to pretreatment variables, and the patient will be rested for 30 s. The sequence will be repeated. The treatment will consist of five sets of eight ventilator hyperinflation breaths.

  • Vibrocompression

    Other intervention

    Vibrocompression will be performed by the physical therapist to produce vibration and will be combined with compression of the patient's chest in the expiratory phase. Every vibrocompression will be interrupted at the end of each expiratory phase to allow free inspiration.

  • Traditional Chest Physical Therapy Program

    Other intervention

    Percussion, Postural Drainage, and Suction

Treatment groups

81 Participants
are divided into 3 treatment groups
Group A: Study Group (A)Active comparator 2 interventions
Group B: Study Group (B)Active comparator 2 interventions
Group C: Control Group (C)Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

Static Compliance

Static compliance (ml/cmH2O).

Time frame
Before, after treatment at Day 1 and Day 4
2

Airway Resistance

Airway Resistance (cmH2O/l/s).

Time frame
Before, after treatment at Day 1 and Day 4
3

Sputum Volume in ml

Airway suction will be carried out immediately after treatment or during treatment if indicated and will be measured as sputum volume in ml.

Time frame
Immediately after treatment at Day 1 and Day 4
4

Peak Expiratory Flow and Peak Inspiratory Flow

Peak Expiratory Flow (l/min) and Peak Inspiratory Flow (l/min)

Time frame
Before, after treatment at Day 1 and Day 4

Secondary outcomes

1

Oxygen Saturation (SPO2)

Peripheral oxygen saturation (SPO2) in percentage

Time frame
Before, after treatment at Day 1 and Day 4

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov
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