Efficacy of a Novel Nanoparticle -Augmented Disinfection Protocol
ConditionPost Operative Pain
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorMinia University
About this trial
The ultimate biological aim of endodontic therapy is to either prevent or heal apical periodontitis. Root canal treatment can fail for various reasons, such as persistent infection, missing canals, ledges, canal transportation, instrument separation, and perforation.
Post-treatment apical periodontitis is an inflammatory response in the tissues surrounding the root tip, triggered by either lingering bacteria from the initial procedure or a new, secondary infection within the canal system. Statistically, this condition affects roughly 5% to 20% of cases where apical periodontitis was present before the initial treatment.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diabetic patients type II of either gender aged from 18-40 years
Permanent mature Maxillary anterior teeth having a baseline periapical lesion (PAI score ≥3).
Disqualifiers
Immuno-compromised patients.
Pregnant women and smokers.
Patients with a history of antibiotic or analgesics intake within the few days before the endodontic treatment.
Teeth with root fractures or perforations.
Trial design
Design model
Parallel
Treatments tested in this trial
Novel Nanoparticle
Procedure/SurgeryTo evaluate efficacy of a Novel Nanoparticle -Augmented Disinfection Protocol in the Non -Surgical Retreatment of Maxillary Anterior Teeth with Periapical Lesions in Type II Diabetic Patients
Treatment groups
28 Participants
are divided into 2 treatment groupsGroup A: Non- surgical retreatment Novel Nanoparticle (NSRN)Active comparator 1 intervention
Group B: Non -surgical root canal retreatment (NSRC)Active comparator 1 intervention
Trial outcomes
Primary outcomes
1
Post Operative Pain
Evaluation of the cases from the pain after the procedures by using point numeric rating scale by another operator at 24, 48 and 72-hours.
Time frame
from 24 hours to 72 hours after the proceduresSponsors and contacts
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Source ClinicalTrials.gov