Efficacy of Integrated Nano-technology in Revascularization of Immature Necrotic Teeth
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorMinia University
About this trial
This trial aims to study the effect of photoactivated disinfection using Diod laser (810 nm) to activate photosensitive nanoparticle chitosan as an endodontic irrigant versus sodium hypochlorite followed by saline and then EDTA 17% on 1) postoperative pain and 2) the success of revascularization in patients with necrotic immature maxillary anterior teeth using a randomized clinical trial design.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
o Immature necrotic maxillary incisor with open apex greater than 1 mm.
Teeth where pulp space are not needed for post and core.
A restorable tooth.
Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
Disqualifiers
o Non-restorable teeth.
Teeth with root fractures, internal or external root resorption.
Teeth with mature fully developed root with closed apex
Patients with any systemic disease that may affect predictable outcome
Trial design
Design model
Parallel
Treatments tested in this trial
regenerative endodontic procedure using blood clot according to AAE
Procedure/Surgeryregenerative endodontic procedure using blood clot to replace the necrotic pulp tissues in immature teeth with a pulp like to tissue to complete root development. using AAE protocol
regenerative endodontic procedure using photo activated nanochitosan 2%
Procedure/Surgeryregenerative endodontic procedure using blood clot to replace the necrotic pulp tissues in immature teeth with a pulp like to tissue to complete root development. using photosensitized nanochitosan for root canal disinfection
Treatment groups
20 Participants
are divided into 2 treatment groupsGroup A: control group: using AAE protocolActive comparator 1 intervention
Group B: test groupExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
pain intensity assessed by numerical rating scale
postoperative pain using numerical rating scale
Time frame
24 hours and 1 week after completion of the procedureSecondary outcomes
1
root development
change of root length
Time frame
6 months, 1 year postoperative2
Apical foramen closure
change in apical foramen diameter
Time frame
6 months, 1 year postoperative3
periapical bone healing
change in the area of periapical lesion
Time frame
6 months, 1 year postoperativeLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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