This study is aimed to compare the clinical efficacy of two different catheter ablation strategies in patients with persistent atrial fibrillation.
Participants will be randomized 1:1 into either the Anatomy-based group or the Emphasize map-guided group
* Anatomy-based group : Pulmonary vein isolation (PVI) using pulsed-field ablation (PFA) with a single-shot multielectrode catheter. * Emphasize map-guided group : PVI using radiofrequency (RF) ablation followed by additional EnSite X-guided pathologic substrate modification.
Participants will be followed for 1 year to compare the incidence of any atrial tachyarrhythmia and other clinical parameters between the two groups.
Adults aged 19 years or older who have voluntarily provided written informed consent to participate in the study
Patients diagnosed with persistent atrial fibrillation (AF) who are scheduled to undergo catheter ablation for AF.
History of prior catheter ablation or MAZE surgery for atrial fibrillation.
Left atrial (LA) diameter exceeding 60 mm.
Patients with end-stage renal disease (ESRD).
History of prior open-heart surgery.
Samsung Medical Center
Lead sponsor
Asan Medical Center
Collaborator
Keimyung University Dongsan Medical Center
Collaborator
Korea University Anam Hospital
Collaborator