ENDOMETRIOSIS - MRI

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-50
SponsorUniversity Hospital, Lille

About this trial

Endometriosis is a frequent pathology with an estimated prevalence of 10% of women of childbearing age. There is no exact correspondence between the symptoms described by the patients and the severity of the lesions, which makes clinical diagnosis difficult. It therefore seems important to improve the complementary examinations available to make the diagnosis more precise and to better study the effectiveness of the treatments implemented. The clinical examination and per-surgical findings of patients with deep pelvic endometriosis show a clear decrease in the mobility of the pelvic organs in relation to each other, but few studies have looked at this mobility, which could however have an implication in explaining the pathophysiology of the disease and the symptomatology of the patients, as well as in the detection of lesions preoperatively. The persistence of hypo-mobility could also help to understand treatment failures.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patient referred for suspected pelvic endometriosis requiring pelvic MRI

Female, nulliparous,

patient with signed written consent, patient with health insurance,

patient willing to comply with all study procedures and duration

Disqualifiers

BMI > 35,

history of hereditary collagen and elastic tissue disease,

history of pelviperitonitis,

history of major pelvic surgery,

Trial population

The population concerns patients referred to the Lille University Hospital for suspected pelvic endometriosis

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Dynamic MRI Sequence

    Other intervention

    Addition of a Dynamic MRI Sequence during the MRI examination performed in routine care

Treatment groups

52 Participants
are divided into 2 treatment groups
Group A: patients with pelvic endometriosis1 intervention
Group B: patients without pelvic endometriosis1 intervention

Trial outcomes

Primary outcomes

1

the mean vertical displacement (in millimeters) measured on the anterior wall of the vagina between rest and maximum pushing force during dynamic MRI

Time frame
Baseline

Secondary outcomes

1

the mean vertical displacement (in millimetres) measured on the cervix between rest and maximum thrust effort during dynamic MRI.

Time frame
Baseline
2

the mean vertical displacement (in millimetres) measured on the posterior wall of the vagina between rest and maximum pushing force during dynamic MRI.

Time frame
Baseline
3

the measurement of variation in mean vertical displacement (in millimetres) on the wall of each pelvic organ at the push effort between the initial dynamic MRI of patients with

Time frame
Baseline
4

the statistical association between the symptoms of patients with endometriosis and the mean vertical displacement (in millimetres) on the wall of each pelvic organ at the push effort during dynamic MRI.

Initial symptoms are associated with initial dynamic MRI data and post therapeutic symptoms are associated with post-therapeutic dynamic MRI data. The symptoms of interest are dysmenorrhea, non-cyclic pelvic pain, dysuria, dychesia, transit disorders (diarrhea/constipation), and dyspareunia.

Time frame
Baseline

Other outcomes

Sponsors and contacts

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