Epidemiology and Household Transmission of Streptococcus Pneumoniae and Respiratory Syncytial Virus
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorMackay Memorial Hospital
About this trial
This household-based prospective cohort study aims to stablish the household transmission of Respiratory syncytial virus and S. pneumoniae especially in the elderly and infants/children as well as inter-relationship between S. pneumoniae and Respiratory syncytial virus.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Indicator case: Babies under 5 months of age were born in Mackay Children's Hospital and had no acute respiratory infection-like symptoms that required medical intervention when they agreed to participate in the trial.
Family members: family members living with the Indicator case, including 2-5 years old siblings, parents and grandparents over 65 years old.
Willing to sign the informed consent form and agree to join the official LINE account to receive research tracking.
Disqualifiers
Babies older than 5 months
Co-morbid medical conditions of the baby such as chronic lung disease, cyanotic congenital heart disease, neuromuscular disease and a primary immunodeficiency.
Family members who do not live with the Indicator case
Family with grandparents younger than 65 years old
Trial population
A household-based prospective cohort study will invite 240 households, having a baby who is discharged from MacKay children's Hospital. The households will be classified into nuclear family type and extended family type. The "Nuclear family type" is defined as husband and wife with baby (aged less than 5 months) and with or without children (2-5) and the "Extended family type" (three-generation family) is defined as husband and wife with baby (aged less than 5 months), children (2-5), and grandparents aged \> 65 years old.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
240 Participants
are grouped into 2 trial groupsGroup A: Nuclear family type
Group B: Extended family type (three-generation family)
Trial outcomes
Primary outcomes
1
Household transmission of Streptococcus pneumoniae and Respiratory syncytial virus
The primary endpoint is the Streptococcus pneumoniae and Respiratory syncytial virus isolation rates in children and their household contacts of different family type.
Time frame
2 years2
The serotype of Streptococcus pneumoniae and Respiratory syncytial virus in post-Prevenar 13 era
The secondary endpoint is the serotype of Streptococcus pneumoniae and Respiratory syncytial virus in post-Prevenar 13 era.
Time frame
2 yearsLocations
Sponsors and contacts
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Mackay Memorial Hospital
Lead sponsor
Merck Sharp & Dohme LLC
Collaborator
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: