1. A predictive model for NARDS was established based on perinatal risk factors. Multivariate Logistic regression analysis was used to screen the independent prenatal risk factors for NARDS. A Logistic regression model was constructed using the above independent risk factors and quantified in a nomogram to construct a visualization model for prenatal prediction of NARDS. 2. The role of ACS in the prevention and treatment of ARDS in near-term/full-term infants.
For neonates with a probability greater than 80% in the prediction model of ARDS, at least one ACS was given before the termination of pregnancy. The GC level of cord blood (taken at birth) and the mRNA levels of α-ENaC, Na-K-atpase and SGK1 in nasal epithelium were measured within 2 hours and 1 day after birth in the ACS intervention group and the control group. The occurrence and severity of pulmonary edema, the occurrence and severity of ARDS, and the mortality rate of NARDS were evaluated by lung ultrasound. The indexes of the two groups were compared horizontally and longitudinally.
The pregnant women with a probability greater than 80% in the prediction model of neonatal acute respiratory distress syndrome and agreed to ACS intervention.
Obtaining patient consent.
the pregnant women with a probability of less than 80% in the neonatal acute respiratory distress syndrome prediction model.
The patient refuses.
Parallel
Dexamethasone
DrugACS intervention were used in the experimental group
The incidence and severity of neonatal acute respiratory distress syndrome
The incidence and severity of neonatal acute respiratory distress syndrome will be compared between the two groups
The incidence and severity of pulmonary edema
The incidence and severity of pulmonary edema will be compared between the two groups
The mortality of NARDS
The mortality rate of NARDS will be compared between the two groups
The mRNA levels of α-ENaC, Na-K-atpase, and SGK1 in nasal epithelium
The mRNA levels of α-ENaC, Na-K-atpase, and SGK1 in nasal epithelium will be compared between the two groups
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The Second Affiliated Hospital of Chongqing Medical University
Lead sponsor
University-Town Hospital of Chongqing Medical University
Collaborator
Children's Hospital of Chongqing Medical University
Collaborator
Chongqing Medical Center for Women and Children
Collaborator
