Background:
Infections in the lower respiratory tract (lungs) are the leading cause of death from infectious disease worldwide. This was true even before the COVID-19 pandemic. Respiratory viruses are still a major health threat. Many of these viruses infect people by penetrating the thin skin that lines the nose. These viruses can also spread easily to other people when they multiply in the tissues that line the nose. Researchers want to learn more about what these viruses do inside the nose, how they get from the nose to the lungs, and how they spread from person to person.
Objective:
To collect cell samples from inside the noses of healthy people. These cells will be stored for use in future research on respiratory diseases.
Eligibility:
Healthy volunteers aged 18 years and older.
Design:
Most participants will have 1 visit on 1 day. They will be asked questions. Those who have a runny nose, coughing, congestion, or fever will be asked to wait up to 21 days before participating.
Participants will be given a slender swab with small bristles at the end. They will rub the inside of their nose with the swab. A clinic staff member will be present to help, if needed.
Participants will provide their name, age, and sex. This information will be encoded so that only certain researchers will know the participants identities.
Participants will not be contacted again....
Aged >=18 years.
Able to provide informed consent.
Willing to allow biological samples and data to be stored for future research.
History of respiratory symptoms including but not limited to runny nose, coughing, congestion, and/or fever within the past 14 days.
NIH and laboratory staff with direct involvement in the operation or maintenance of the repository are excluded from participation.
An individual who has any condition that, in the judgment of the investigator, may put them at undue risk or make them unsuitable for participation in the study will be excluded.
Healthy volunteers, aged 18 years and older, may be recruited from the general public, people working at and/or visiting Rocky Mountain Laboratories (RML), and NIH staff members and their family/contacts.
Cohort
Cross-sectional
Not listed
To obtain nasal epithelium brushes from healthy volunteers for 1) establishment of upper respiratory tract organoids, 2) assay validation, and 3) use for research into the pathogenesis of emerging respiratory viruses.
To obtain nasal epithelium brushes from healthy volunteers for 1) establishment of upper respiratory tract organoids, 2) assay validation, and 3) use for research into the pathogenesis of emerging respiratory viruses.
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This trial is not recruiting at the moment. You can still explore other options:
