Health TrialsbyHealthPanel

Evaluation of Aqueous Humor DEL-1 and IL-17 Levels in Diabetic Cataract Patients

ConditionsDiabetic Group (n=30)Non-diabetic Group
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50-80
SponsorUşak University

About this trial

By comparing DEL-1 and IL-17 levels in the aqueous humor of diabetic cataract patients with the aqueous humor of non-diabetic patients, we aim to understand the biochemical effects of diabetes-related inflammatory processes in the eye.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Cataract diagnosed and surgery planned

Patients without any other ocular pathology other than cataract.

Type 2 DM for at least 5 years in the diabetic group

Disqualifiers

Patients with previous intraocular surgery

Those with inflammatory eye diseases (e.g. uveitis)

Those with autoimmune diseases or systemic inflammatory diseases

Those receiving local or systemic steroid therapy

Trial design

Design model

Crossover

Treatments tested in this trial

  • Del 1

    Diagnostic test

    During cataract surgery, approximately 0.1-0.2 mL of aqueous humor will be sampled with a sterile 27 gauge syringe before viscoelastic is introduced into the anterior chamber. DEL 1 will be analyzed by ELISA

  • IL 17

    Diagnostic test

    During cataract surgery, approximately 0.1-0.2 mL of aqueous humor will be sampled with a sterile 27 gauge syringe before viscoelastic is introduced into the anterior chamber. IL 17 levels will be analyzed by ELISA

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Diabetic cataract patientsExperimental treatment 2 interventions
Group B: Non-diabetic cataract patientsSham comparator 2 interventions

Trial outcomes

Primary outcomes

1

DEL-1 and IL-17 levels

To be measured quantitatively with ELISA kits, pg/mL

Time frame
Perioperative

Secondary outcomes

1

Correlation between DEL-1 and IL-17

Pearson or Spearman correlation analyses will be used. pg/mL

Time frame
Perioperative
2

Association of biomarker levels with HbA1c

It will be analyzed by multivariate regression analysis.mmol/mol

Time frame
Perioperative
3

Impact of demographic factors

The effect of age, gender and duration of diabetes on biomarkers will be statistically analyzed. Years, gender

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Uşak University

Lead sponsor

Source ClinicalTrials.gov
Apply now