Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorHarran University
About this trial
The purpose of this clinical study is to compare the effects of mouthwashes containing Chlorhexidine and tea tree oil on edema, pain, and trismus after the extraction of impacted third molars. Additionally, the effects on periodontal health will be examined by comparing the gum healing processes of patients using both mouthwashes.The main questions it aims to answer are:
1. Tea tree oil, said to have anti-inflammatory and antibacterial effects, could be an alternative to chlorhexidine in reducing postoperative complications after impacted tooth extraction. 2. Does tea tree oil, which has antimicrobial effects, have as positive an impact on periodontal health as chlorhexidine?Researchers will compare tea tree oil to chlorhexidine (routinely prescribed after the extraction of an impacted wisdom tooth) to see if tea tree oil works to decrease postoperative complications.
Participants will:
For 7 days after the operation, they will gargle with chlorhexidine mouthwash or mouthwash containing tea tree oil 3 times a day. They will come to the clinic for check-ups and measurements on the 2nd and 7th days after the operation. They will record their pain levels and the number of painkillers they take daily.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Individuals undergoing extraction of Class 2, Class B mandibular third molars impacted in the lower jaw (Pell & Gregory).
Individuals aged 18-65.
Individuals must be in stable general health (e.g., free of serious cardiovascular or kidney disease).
Individuals willing to use tea tree extract or other treatments.
Disqualifiers
Individuals with a known allergy or hypersensitivity to tea tree extract.
Individuals with serious illnesses such as heart failure or kidney disease. Patients with bleeding disorders.
Individuals during pregnancy and breastfeeding.
Individuals taking medications that may interact with tea tree extract (e.g., blood thinners or antihypertensives)
Trial design
Design model
Parallel
Treatments tested in this trial
Chlorhexidine Gluconate 0.12% Mouthwash
DrugParticipants will be prescribed to gargle with chlorhexidine, which is the routine recommendation after brushing their teeth 3 times a day for 7 days after the impacted tooth extraction.
Tea Tree Oil mouthwash
DrugParticipants will be prescribed to gargle with tea tree oil-containing water after brushing their teeth three times a day for 7 days following the extraction of an impacted tooth.
Treatment groups
54 Participants
are divided into 2 treatment groupsGroup A: chlorhexidine groupActive comparator 1 intervention
Group B: tea tree oil groupExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
pain VAS measurement
The patient will be given a chart with a 7-day VAS scale for pain control after tooth extraction. They will be asked to record their pain daily on a scale of 0 (no pain) to 10 (the worst imaginable pain) for 7 days, and to note how many painkillers they used.
Time frame
preoperative, postoperative day 2, post operative day 72
amount of mouth opening
Restriction in mouth opening for 7 days after impacted tooth extraction surgery
Time frame
preoperative, postoperative day 2, post operative day 73
distance from the angulus to the labial commissure, external eye angle, tragus, pogonion, and nasal line
The amount of facial swelling during the 7 days following impacted tooth extraction surgery
Time frame
preoperative, postoperative day 2, post operative day 7Secondary outcomes
1
Pocket depth measurement of the second molar tooth next to the extraction site and assessment of plaque presence
The level of periodontal healing of teeth in the adjacent area during the 7 days following impacted tooth extraction surgery
Time frame
preoperative, postoperative day 2, post operative day 7Sponsors and contacts
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Source ClinicalTrials.gov