Exercise Effects on Adipose Tissue Structure and Function
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorUniversity of Michigan
About this trial
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age: 18-40
Body Mass Index: 27-45 kg/m2
No regularly planned exercise/physical activity for at least 6 months
Women must have regularly occurring menses and must be premenopausal
Disqualifiers
Evidence/history of cardiovascular or metabolic disease
Medications known to affect lipid or glucose metabolism, or inflammation
Weight instability ≥ ± 6 pounds in the last 3 months
Tobacco or e-cigarette users
Trial design
Design model
Parallel
Treatments tested in this trial
Exercise
BehavioralParticipants will complete a moderate intensity continuous exercise 4 days/week.
No exercise
BehavioralParticipants will remain sedentary throughout the duration of the study.
Treatment groups
46 Participants
are divided into 2 treatment groupsGroup A: ExerciseExperimental treatment 1 intervention
Group B: No exerciseExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Oral Glucose Tolerance Test (OGTT)
A test in which glucose is given and blood samples taken afterward to determine how quickly it is cleared from the blood will be completed at each clinical visit appointment..
Time frame
2 hours2
Adipose Tissue Fibrosis
measured histologically using Sirus Red Staining, quantified using ImageJ software at each clinical visit appointment.
Time frame
30 minutes3
Muscle Capillarization
measured immunohistochemically using an antibody for CD31, quantified using ImageJ software at each clinical visit appointment.
Time frame
30 minutes4
Adipose Capillarization
measured immunohistochemically using an antibody for CD31, quantified using ImageJ software at each clinical visit appointment.
Time frame
30 minutesSecondary outcomes
1
Blood Lipid Profile
A panel of blood tests that screens for abnormalities in blood lipids will be measured at each clinical visit appointment.
Time frame
15 minutes2
Blood Pressure
The pressure of circulating blood against the walls of blood vessels will be measured at screening and each clinical visit appointment.
Time frame
10 minutesSponsors and contacts
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Source ClinicalTrials.gov