Exercise Intensity and Postprandial Effects of Breaking Sedentary Behavior in Overweight Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age30-45
SponsorHacettepe University
About this trial
The purpose of this study is twofold: (1) to determine whether breaking up prolonged sitting with aerobic or sprint cycling breaks reduces postprandial blood glucose, insulin, CRP, and blood pressure, which are established risk markers for cardiometabolic diseases; and (2) to assess substrate oxidation during this period in order to identify which exercise condition promotes the greatest increase in fat oxidation.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Being physically inactive (not doing at least 150 minutes/week of structured exercise).
Being sedentary (having a daily sedentary time/day for >7 hours).
Having a BMI between 25 and 29.9 kg/m2.
Having a history of regular menstrual cycles for female participants.
Disqualifiers
Taking any acute or chronic medication or supplement that may affect metabolism.
Having an acute or chronic illness that limits exercise (musculoskeletal problems, cardiovascular disorders, respiratory problems, etc.).
Consuming tobacco products.
Meeting 3 or more of the metabolic syndrome criteria (waist circumference of 102 cm or more in men, 88 cm or more in women, triglyceride level of 150 mg/dL or higher, HDL cholesterol level below 40 mg/dL in men and 50 mg/dL in women, blood pressure of 130/85 mmHg or higher, fasting blood glucose level of 100 mg/dL (5.6 mg/L) or higher).
Trial design
Design model
Crossover
Treatments tested in this trial
Aerobic Exercise Intervention
Other interventionIn the aerobic exercise condition, participants will perform 2 minutes of moderate-intensity (%50 Wattmax) continuous cycling.
Sprint Exercise Intervention
Other interventionIn the sprint condition, participants will complete a 10-second sprint at %200 Wattmax level, as determined during the preliminary test.
Sedentary Behaviour Intervention
Other interventionParticipants will remain seated for a total duration of 7 hours. During this period, they will be instructed to minimize excessive movement and will only be permitted to rise from the chair for voiding purposes.
Treatment groups
18 Participants
are divided into 3 treatment groupsGroup A: Sedentary: Participants will remain seated for 7 h.Experimental treatment 1 intervention
Group B: Breaking up sitting with aerobic exercise interruptionsExperimental treatment 1 intervention
Group C: Breaking up sitting with sprint exercise interruptionsExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Insulin
Postprandial insulin. Net incremental area under the curve and total area under the curve for each 7 h condition will be calculated for insulin.
Time frame
7 hour for each experimental conditionSecondary outcomes
1
Glucose
Postprandial glucose. Net incremental area under the curve and total area under the curve for each 7 hour condition will be calculated for glucose.
Time frame
7 hour for each experimental condition2
CRP
Postprandial CRP. Net incremental area under the curve and total area under the curve for each 7 h condition will be calculated for CRP.
Time frame
7 hour3
Substrate oxidation
Postprandial substrate oxidation. During each experimental visit, for 7 hours, volunteers' respiratory data will be collected using a direct calorimeter with canopy hood in lying position for 10 minutes at 0, 2th, 5th, and 7th hours. The volunteers' resting fat and carbohydrate oxidations will be determined from the obtained data.
Time frame
0, 2th, 5th, 7th hours4
Blood pressure
Postprandial arterial blood pressure will be measured hourly for 7 h using an automatic blood pressure monitor with a cuff of appropriate size. The systolic and diastolic BP values measured will be recorded, and the mean arterial pressure will be calculated.
Time frame
7 hourSponsors and contacts
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Source ClinicalTrials.gov