Clinical trials

151

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Condition / disease
Location
Status: Not yet recruiting

Turkish Validation of the HOOS-12

The Hip Disability and Osteoarthritis Outcome Score-12 (HOOS-12) is a short patient-reported outcome measure developed to assess pain, function, and hip-related quality of life in individuals with hip osteoarthritis. Although widely used internationally, a validated Turkish version is currently unavailable. This study aims to translate and culturally adapt the HOOS-12 into Turkish and evaluate its psychometric properties, including internal consistency, test-retest reliability, construct validity, structural validity, responsiveness, and measurement error, in Turkish-speaking patients with hip osteoarthritis.

Participants needed: 150
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Aug 18, 2026
Eligibility criteria

Age 18 years or older. [+6]

Previous total hip arthroplasty on the affected side. [+9]

Status: Not yet recruiting

High-Intensity Interval Training for Walking and Function Across Different Multiple Sclerosis Disability Levels

Multiple Sclerosis (MS) is a chronic neurological disease that can affect daily functioning, mobility, and overall quality of life. High-Intensity Interval Training (HIIT) is known to be a time-efficient exercise approach that improves exercise capacity and reduces fatigue in MS. However, current research lacks sufficient data on how HIIT affects individuals with different levels of disability. The main purpose of this study is to evaluate the effects of a stationary bicycle-based HIIT protocol on maximum walking distance, fatigue, balance, muscle strength, endurance, gait speed, and quality of life in MS patients across three different disability levels: mild, moderate, and severe (classified according to Expanded Disability Status Scale - EDSS scores). Participants will complete a cycle ergometer-based HIIT program. Assessments will be conducted at three time points: Before starting the exercise program (baseline) Immediately after completing the program (post-treatment) 4 weeks after the completion of the program (follow-up) To ensure unbiased results, a triple-blind design will be used, meaning the outcome assessor, the treating physiotherapist, and the data analyst will be blinded to group assignments. The findings aim to help clinicians tailor personalized, effective HIIT protocols based on a patient's specific disability level rather than using a standardized, one-size-fits-all approach in MS rehabilitation.

Participants needed: 30
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Aug 18, 2026Locations: 1
Eligibility criteria

Be between the ages of 18 and 65, [+5]

Having a severe cardiovascular, orthopedic, respiratory, or metabolic disease, [+4]

Status: Recruiting

Motor Imagery and Action Observation for Gait Function in MS

This study will investigate whether mentally simulating walking movements while watching others walk can improve walking performance in individuals with Multiple Sclerosis (MS). Participants will be divided into two groups: one group will watch walking videos and imagine themselves walking, while the other group will watch nature scenes. The study will measure muscle activity and walking patterns to assess the effects. The results may help support the use of mental practice techniques to improve mobility in people with MS.

Participants needed: 20
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Aug 17, 2026Locations: 1
Eligibility criteria

A confirmed diagnosis of multiple sclerosis (MS) by a neurologist [+2]

Presence of serious health conditions affecting the muscles, heart, lungs, or me... [+5]

Status: Not yet recruiting

Immediate Effects of Kinesio Taping on Thoracic Outlet Syndrome

The goal of this clinical trial is to evaluate the immediate effects of Kinesio Taping compared with sham taping in adults with Thoracic Outlet Syndrome (TOS). The study aims to determine whether a single application of Kinesio Taping provides greater improvements in symptom severity, grip strength, and hand dexterity than sham taping. The main questions it aims to answer are: Does a single application of Kinesio Taping reduce symptom severity and improve tolerance to the Roos test compared with sham taping? Does a single application of Kinesio Taping improve grip strength and hand dexterity compared with sham taping? Researchers will compare participants receiving Kinesio Taping with those receiving sham taping to determine whether the observed effects are attributable to the therapeutic application of Kinesio Taping rather than nonspecific or placebo effects. Participants will: * undergo baseline assessments of symptom severity during the Roos test, Roos test completion time, grip strength, and hand dexterity; * be randomly assigned to receive either Kinesio Taping or sham taping; * undergo immediate post-intervention assessments using the same outcome measures.

Participants needed: 32
Trial details
Age: 20-45Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Aug 10, 2026Locations: 1
Eligibility criteria

Clinical diagnosis of Thoracic Outlet Syndrome (TOS) confirmed by a thoracic sur... [+2]

History of fracture or surgery involving the cervical spine, shoulder, elbow, wr... [+5]

Status: Recruiting

Brain-Heart Axis in Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM) is associated with chronic hyperglycemia and metabolic disturbances that affect not only glucose metabolism but also the central nervous system, autonomic nervous system, and cardiovascular function. Growing evidence suggests that individuals with T2DM are at increased risk of cognitive impairment, autonomic dysfunction, reduced functional capacity, and psychological distress. However, the interactions among metabolic status, brain activity, cardiac autonomic regulation, functional performance, and mental health have not been comprehensively investigated within a single study. This cross-sectional study aims to investigate the relationships between metabolic abnormalities and brain-heart axis function in adults with T2DM. Approximately 50 participants aged 40-65 years with a confirmed diagnosis of T2DM will undergo comprehensive assessments, including resting electroencephalography (EEG), heart rate variability (HRV), functional capacity tests (1-Minute Sit-to-Stand Test and 6-Minute Walk Test), cognitive function using the Montreal Cognitive Assessment (MoCA), physical activity using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), and psychological status using the Depression Anxiety Stress Scale (DASS-21). Clinical and metabolic variables, including HbA1c, fasting blood glucose, lipid profile, and inflammatory markers, will also be collected from medical records. The primary objective is to determine whether metabolic disturbances are associated with alterations in EEG-derived brain activity and HRV-derived autonomic function and whether these changes are related to cognitive performance, functional capacity, physical activity, and psychological well-being. Correlation analyses, path analysis, and structural equation modeling will be used to explore direct and indirect relationships among these variables. The findings are expected to improve understanding of the brain-heart axis in T2DM and provide evidence for multidimensional assessment strategies to support early detection of neurocardiac dysfunction and optimize rehabilitation approaches.

Participants needed: 46
Trial details
Age: 40-75Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Aug 11, 2026Locations: 1
Eligibility criteria

Adults aged 40 to 75 years. [+3]

Diagnosis of neurological, psychiatric, orthopedic, or other systemic diseases t... [+4]

Status: Recruiting

Unilateral and Bilateral Resistance Training in Hypertension

Hypertension is associated with autonomic nervous system dysfunction, reduced muscle strength, and impaired functional capacity, all of which contribute to increased cardiovascular risk and decreased quality of life. Resistance training is recommended as a non-pharmacological intervention for hypertension; however, it remains unclear whether unilateral and bilateral resistance training produce different physiological adaptations, particularly regarding cardiac autonomic function. This randomized controlled trial aims to compare the effects of unilateral and bilateral resistance training on heart rate variability (HRV), muscle strength, and functional capacity in adults with hypertension. Eligible participants aged 40-75 years with a confirmed diagnosis of hypertension will be randomly allocated to one of three groups: a unilateral resistance training group, a bilateral resistance training group, or a control group. Randomization will be performed using a computer-generated block randomization procedure with sex stratification to ensure balanced group allocation. Participants in the two intervention groups will complete a supervised 12-week resistance training program, performed twice weekly at an intensity of 60-70% of one-repetition maximum (1RM). The unilateral training group will perform exercises using one limb at a time, whereas the bilateral training group will perform the same exercises simultaneously with both limbs. The control group will receive no structured exercise intervention during the study period but will receive general information regarding the benefits of physical activity. Assessments will be conducted at baseline and after the 12-week intervention. The primary outcome will be heart rate variability measured using a Polar H10 heart rate sensor and Elite HRV software. Secondary outcomes will include peripheral muscle strength assessed by one-repetition maximum testing, functional capacity assessed using the Six-Minute Walk Test and the Glittre Activities of Daily Living Test, and blood pressure measured using a sphygmomanometer. The findings of this study are expected to provide evidence regarding the optimal resistance training strategy for improving autonomic function and physical performance in individuals with hypertension, thereby supporting the development of safer and more individualized exercise prescriptions.

Participants needed: 54
Trial details
Age: 40-75Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Aug 7, 2026Locations: 1
Eligibility criteria

Adults aged 40 to 75 years. [+3]

Presence of cardiovascular diseases other than hypertension. [+7]

Status: Recruiting

Comparison of the Effects of Long-Term Rowing Training in Professional Rowers

This study aims to compare the effects of long-term rowing training on aerobic capacity, physical fitness, heart rate variability, and psychological performance in novice rowers, professional rowers, and healthy controls. Approximately 60 adults aged 18-65 years will be enrolled and allocated into three groups: novice rowers, professional rowers, and a non-exercising control group. Participants in the rowing groups will complete an 8-week supervised rowing ergometer training program (twice weekly), while the control group will maintain their usual daily activities without structured exercise. Assessments will be performed before and after the intervention and will include aerobic capacity (shuttle walk test, 500-m and 2000-m rowing ergometer tests), muscle strength, muscle power, muscular endurance, core stability, flexibility, agility, posture, heart rate variability, flow state, and mental toughness. The study is designed to provide a comprehensive evaluation of the physiological and psychological adaptations associated with rowing training at different levels of experience and to identify factors that distinguish novice and elite rowers.

Participants needed: 54
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Aug 7, 2026Locations: 1
Eligibility criteria

Not listed

Status: Not yet recruiting

Anticipated Stigma, Illness Identity, and Quality of Life in Male Hypogonadism

This study aims to systematically compare the levels of anticipated illness stigma and illness identity among men diagnosed with hypogonadism to those of men with other chronic endocrine conditions (e.g., diabetes mellitus, hypothyroidism, and hypertension). Furthermore, it examines whether these psychosocial variables predict quality-of-life deterioration specifically within the hypogonadism cohort.

Participants needed: 90
Trial details
Age: 18+Biological sex: MaleType: ObservationalSponsor: Hacettepe UniversityUpdated: Aug 7, 2026Locations: 2Duration: 1 Day
Eligibility criteria

Male, aged 18 years or older. [+10]

Active psychiatric diagnosis (e.g., active psychosis, bipolar disorder). [+6]

Status: Recruiting

Effectiveness of Conservative Interventions in the Treatment of Trigger Finger

There is no study in the literature comparing the effectiveness of ESWT and splint therapy, which are the most commonly used approaches in the treatment of Trigger Finger (TF). The aim in this study is to investigate the effectiveness of ESWT and splint therapy used in the treatment of TF.

Participants needed: 54
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Aug 5, 2026Locations: 1
Eligibility criteria

Volunteering [+3]

Being pregnant [+5]

Status: Recruiting

The Effect of Fermented Grape Juice Consumption on Fibromyalgia Patients

The goal of this clinical trial is to learn if a traditional grape-based fermented drink called hardaliye helps treat fibromyalgia in adult women. We will also learn whether adding hardaliye to a personalized nutrition plan works better than using either one alone. The main questions are: Does diet + hardaliye improve antioxidant status and lower oxidative stress more than diet only or hardaliye only? Does diet + hardaliye lower inflammation (TNF-α, IL-6, hs-CRP) and raise SIRT1 levels? Do these changes relate to less pain and better symptoms (fibromyalgia impact, gut symptoms, sleep, mood)? Are there benefits for weight, waist size, blood pressure, and blood lipids? How the groups are compared: Researchers will compare three groups for 8 weeks: Diet + Hardaliye (personalized medical nutrition plan + one 200 mL bottle of hardaliye daily) Diet only (personalized medical nutrition plan) Hardaliye only (usual diet + one 200 mL bottle of hardaliye daily) Participants will: Drink one 200 mL bottle of hardaliye each day if assigned to Diet + Hardaliye or Hardaliye only Follow a personalized nutrition plan if assigned to Diet + Hardaliye or Diet only Visit the clinic at the start and end of the study, with brief check-ins around weeks 2, 4, and 6 Give blood samples before and after the 8-week period Complete short questionnaires on pain, fibromyalgia impact, gut symptoms, sleep, and mood Keep simple logs of daily drink intake and diet plan adherence, and report any side effects Who can join: Adult women (20-40 years) with doctor-diagnosed fibromyalgia and BMI 25.0-29.9 kg/m² who meet the study's health and medication criteria.

Participants needed: 45
Trial details
Age: 20-40Biological sex: FemaleType: InterventionalSponsor: Hacettepe UniversityUpdated: Jul 31, 2026Locations: 1
Eligibility criteria

Female, 20-40 years [+4]

Age <20 or >40 [+9]

Status: Not yet recruiting

The Effect of Individual Sodium Citrate Consumption on Repeated Sprint Performance in Female Soccer Players

The aim of this research is to determine whether sodium citrate supplementation, taken at the best individual time, would improve repeated sprint performance in professional female soccer players. The main questions it aims to answer are: 1. Does sodium citrate improve sprint times, peak power, minimum power, and mean power during repeated sprints? 2. Does sodium citrate lower fatigue index (the drop in power across sprints) during repeated sprint exercise? 3. Does sodium citrate change blood bicarbonate, pH, and lactate levels before and after exercise? 4. Does sodium citrate affect how hard exercise feels (perceived exertion)?

Participants needed: 20
Trial details
Age: 18-25Biological sex: FemaleType: InterventionalSponsor: Hacettepe UniversityUpdated: Jul 30, 2026
Eligibility criteria

Female professional soccer players competing in the Turkish Women's Third League [+6]

Use of oral contraceptives [+6]

Status: Recruiting

The Effect of a Virtual Reality-Based Mindfulness Intervention on Anxiety, Comfort, Sleep, and Fatigue in Breast Cancer Patients Undergoing Chemotherapy

Breast cancer is a public health issue with a high incidence among women worldwide, and its prevalence continues to increase each year. A breast cancer diagnosis brings significant physical, emotional, social, economic, and occupational changes. Chemotherapy, one of the most commonly used treatment modalities in cancer therapy, causes various physical and emotional symptoms while treating the disease. However, it is well known that these symptoms induced by chemotherapy can be prevented or alleviated through effective treatment and nursing interventions. Recently, virtual reality (VR) and mindfulness-based interventions have been reported as effective tools and methods for managing the physical and psychological symptoms experienced by cancer patients. The present study aims to evaluate the effect of a VR-integrated mindfulness-based intervention on anxiety, comfort, sleep, and fatigue levels among women newly diagnosed with breast cancer, both before and during chemotherapy treatment. The study is designed as a randomized controlled trial (RCT). The study population will consist of individuals diagnosed with breast cancer at the Oncology Outpatient Clinic of Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital between May 2025 and December 2026. The study sample will include female breast cancer patients who are scheduled to receive adjuvant chemotherapy, meet the inclusion criteria, and volunteer to participate in the study. According to the power analysis (with a 30% additional error margin), a total of 50 participants will be included - 25 in the intervention group and 25 in the control group. The data will be collected using the following instruments: Patient Information Form, Beck Depression Inventory, Cancer Fatigue Scale, General Comfort Questionnaire-Short Form, State Anxiety Inventory, Jenkins Sleep Scale, and the Mindfulness-Based Self-Efficacy Scale. It is expected that, as a result of this study, compared to the control group, participants in the intervention group who receive the VR-Mindfulness intervention during breast cancer treatment will demonstrate reduced levels of fatigue and anxiety and improved comfort and sleep quality.

Participants needed: 50
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Hacettepe UniversityUpdated: Jul 28, 2026Locations: 1
Eligibility criteria

Not listed

Status: Not yet recruiting

Ultrasound Measurement of Skin-to-Epiglottis Distance for Prediction of Difficult Airway in Adult Patients

This prospective observational study aims to evaluate the predictive value of ultrasound-measured skin to epiglottis distance for difficult airway in adult patients undergoing elective or emergency procedures requiring airway management. The correlation between ultrasound measurements and standard airway assessment parameters will be analyzed.

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Jul 17, 2026Locations: 1
Eligibility criteria

≥18 yaş elective surgery

emergency surgery [+2]

Status: Recruiting

Effects of Basic Body Awareness Therapy on Gait and Plantar Pressure in Healthy Young Adults

This interventional study will evaluate the effects of Basic Body Awareness Therapy (BBAT) on gait and plantar pressure outcomes in healthy young adults. Participants aged 18 to 25 years will receive a 12-week BBAT program delivered twice weekly by a physiotherapist trained in BBAT. Outcomes will be assessed at baseline, after the 12-week intervention, and at 3-month follow-up. The primary aim is to determine changes in gait speed and other spatiotemporal gait parameters during the 10-meter walk test. Secondary aims are to examine changes in static and dynamic plantar load distribution, right-left load sharing, and regional plantar pressure parameters. The study hypothesizes that BBAT will improve gait speed, reduce right-left differences in spatiotemporal gait parameters, improve bilateral load distribution during static stance and walking, and maintain these gains at 3-month follow-up.

Participants needed: 33
Trial details
Age: 18-25Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Jul 15, 2026Locations: 1
Eligibility criteria

Aged 18 to 25 years [+4]

History of neurological, vestibular, or rheumatological disease [+5]

Status: Recruiting

The Relationship Between Lost Extremity Percentage and Postural Control, Neck and Low Back Pain, Daily Living Activities, and Reaction Time in Individuals With Unilateral Upper Limb Amputation

This observational study aims to examine the relationship between the percentage of limb loss and functional outcomes in individuals with unilateral upper limb amputation. Upper limb amputation can affect posture, balance control, pain levels, daily living activities, hand function, and reaction time. However, limited research has investigated how the amount of limb loss influences these outcomes. Participants between 18 and 65 years of age who use a myoelectric or bionic prosthesis will undergo a series of assessments. These assessments include measurements of postural control using a force platform, posture analysis, evaluation of neck and low back pain using a visual analog scale, daily living activities using a validated questionnaire, hand dexterity using the Box and Block Test, and reaction time using a visual stimulus device. The study does not involve any intervention or treatment. All evaluations will be performed during a single assessment session. The results of this study may help improve rehabilitation planning and provide better understanding of functional changes associated with different levels of limb loss in people with upper limb amputation.

Participants needed: 15
Trial details
Age: 18-65Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Jul 1, 2026Locations: 1
Eligibility criteria

Adults aged 18-65 years [+3]

Bilateral upper limb amputation [+3]

Status: Not yet recruiting

Impact of a Web-Based Mind-Body Awareness Program on Women Undergoing Infertility Treatment

The goal of this two-group parallel randomized controlled study is to determine the effect of a web-based mind-body-based awareness program based on Meleis Transition Theory on fertility awareness and readiness levels in women receiving infertility treatment.

Participants needed: 78
Trial details
Age: 23-45Biological sex: FemaleType: InterventionalSponsor: Hacettepe UniversityUpdated: Jul 2, 2026Locations: 1
Eligibility criteria

Volunteering to participate in research [+7]

Women applying for frozen embryo transfer without ovarian stimulation [+3]

Status: Not yet recruiting

Effects of a 12-week T10 Exercise Program on Shooting Performance, Upper Extremity Function, Balance and Reaction Time in Competitive Air Pistol Athletes

Air pistol shooting requires a high level of postural stability, upper extremity neuromuscular control, and concentration to achieve optimal performance. Prolonged maintenance of the shooting position may lead to shoulder muscle fatigue, reduced joint stability, and impaired shooting accuracy. Although sport-specific exercise programs have been recommended to improve physical performance in shooters, the effectiveness of the T10 exercise program has not yet been investigated in this population. This randomized controlled trial aims to evaluate the effects of a 12-week T10 exercise program, in addition to routine training, on shooting performance in competitive air pistol athletes. Secondary outcomes include upper and lower extremity functional performance, balance, muscular endurance, upper extremity stability, grip strength, medicine ball throw performance, and visual and auditory reaction time. Participants will be randomly allocated to either an intervention group receiving the T10 exercise program plus routine training or a control group continuing routine training alone. Assessments will be performed at baseline and after the 12-week intervention. The findings of this study may provide evidence for the effectiveness of a sport-specific neuromuscular exercise program in enhancing shooting performance and physical function in competitive air pistol athletes.

Participants needed: 24
Trial details
Age: 18-40Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Jul 2, 2026Locations: 1
Eligibility criteria

Age between 18 and 40 years. [+4]

Current upper extremity musculoskeletal injury or pain. [+9]

Status: Not yet recruiting

The Effect of Changes in the Frequency of Endotracheal Tube Repositioning in Intensive Care Units on the Prevention of Oral Mucosal Pressure Injuries

Intensive care units (ICUs) are care centers equipped with a wide range of technological tools and devices used to provide the highest level of care to individuals whose lives are at risk, requiring a multidisciplinary team approach. Patients may require respiratory support from a ventilator to maintain breathing. In the intensive care unit, patients' breathing is maintained using a medical device called an endotracheal tube (ETT). ETTs can cause injuries due to the constant pressure they exert on the patient's mouth and lip area. Therefore, nurses must secure the ETT at specific times to different points in the mouth area (right and left sides of the mouth) to prevent these injuries. Injuries to the mucosa caused by medical equipment are defined as "mucosal membrane pressure injuries (MMPI)." One such injury is an injury to the mouth. Injuries occurring in the mouth are caused by the pressure of the tubes that enable the patient to breathe in and out. "The Effect of Changes in the Frequency of Endotracheal Tube Repositioning in Intensive Care Units on the Prevention of Oral Mucosal Pressure Injuries" is a doctoral thesis study; the aim of this study is to investigate the effect of differences in the time interval for changing the position of the tube in the lip region on the prevention of injuries occurring in the mouth in patients monitored with ETT in the ICU. A review of the literature revealed that there are gaps in studies conducted at the international or national level on this subject, and that there is no definitive time guideline for changing (repositioning) the tube in the lip area. The study will include patients over the age of 18 who are being monitored with an ETT in their mouth, who did not have any injuries in the mouth area at the time of admission to the ICU, who have not had the tube in their mouth for more than 24 hours, who are in moderate to good general condition, and whose first-degree relatives or legal presentative have given permission for them to participate in the study. In the study, the follow-up and evaluation of patients will be limited to fourteen days after tube insertion. Exclusion Criteria; Differences in respiratory support, Pre-existing artificial airway, Oncological conditions, Neurological and behavioral factors, Positional constraints, Sensory/perceptual impairment, Pre-existing injury. Patients who are discharged or transferred during the fourteen-day follow-up period will be excluded from the study. According to the sample calculation for the study, a total of 230 patients (115 volunteers in the 4-hour group and 115 volunteers in the 8-hour group) will be sufficient. In the study, patients will be stratified according to their APACHE II scores. ICU nurses are not bound by any specific time for securing the ETT. Nurses positioned the tube fixation site at the right lip edge/left lip edge/mid-lip line; however, since they were not bound by a specific time-based rule, tube care was nurse-specific. In this study, the location of tube fixation will be recorded through observation to determine the effect of tube fixation on the formation of oral injuries. This study is planned to be completed within a 24-month timeframe between May 30, 2026, and June 15, 2027. This research is a scientific research (doctoral thesis) study. The daily tube care of volunteers is already in place, and we emphasize that this research will not affect/interfere with the treatment and follow-up of volunteers, and that volunteers will not be negatively affected by the study in any way. The principal investigator will randomly assign volunteers being monitored with ETT to groups using a computer system and will request nurses to reposition their ETTs based on the time intervals (4 hours-8 hours) within these groups. At the same time, the researcher will collect relevant clinical data that may affect pressure injuries in patients (age, gender, smoking history, body mass index, medical history, ICU admission diagnosis, SOFA, RASS and APACHE II scores, Glasgow Coma Scale, laboratory findings (C-reactive protein, white blood cell, Hemoglobin, Hematocrit, Total Protein, Albumin, pH, PO2, Blood Sugar Level), Nutritional Status (Route and Type of Nutrition, Product), Medication Support (Sedatives, Inotropes, Antibiotics, Steroids), ETT-Related Data (Number, Depth, Fixation Site, Repositioning Time), Eilers Oral Assessment Guide and Oral Care Frequency, Braden Pressure Ulcer Risk Assessment Scale and Overall Body Pressure Ulcer Presence, Reaper Oral Mucosa Pressure Injury Scale Grade data, etc.). The follow-up period in the study will be fourteen days, during which the principal investigator will record the patients' personal health data mentioned above and terminate the follow-up of patients who develop pressure injuries in the oral mucosa. Our expectation from the study is that no injuries will occur in the mouth. In the event of a possible injury, the intervention will be terminated immediately.

Participants needed: 230
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Jun 25, 2026
Eligibility criteria

The study will include patients over the age of 18, receiving MV support with or...

Status: Recruiting

Cardiopulmonary Responses to 6-Minute Stepper Test in Bronchiectasis Versus Healthy Controls

Individuals with bronchiectasis exhibit productive cough and recurrent lung infections as well as reduced exercise capacity, physical activity level, and respiratory and peripheral muscle strength. 6-minute walk test (6MWT) is often used to assess exercise capacity in chronic lung diseases. 6MWT is recommended to be performed along a flat corridor, at least 30 m long, with low pedestrian traffic, on a hard surface. To overcome technical limitations during 6MWT, 6-minute stepper test (6MST) has been proposed to assess exercise capacity. Another test that provides information about exercise capacity is the 1-minute sit-to-stand test (1STS). To our knowledge, there is limited information about different exercise tests including 6MST and 1STS and cardiopulmonary responses to these tests in individuals with bronchiectasis. Therefore, this study aims to compare the responses to the 6MST between individuals with bronchiectasis and healthy controls and to investigate the relationships among 6MST, 6MWT, and 1STS responses and muscle strength.

Participants needed: 60
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Jun 25, 2026Locations: 1
Eligibility criteria

Being 18 years of age and older, [+4]

Being in an acute exacerbation period, [+6]

Status: Recruiting

Health Literacy, Physical and Cognitive Function, Health-related Behaviors, and Quality of Life in COPD

Health literacy is important for controlling disease progression and living a healthy life with illness. High health literacy is associated with higher cognitive performance and lower health-related quality of life. Physical, psychological, and social impairments are seen in chronic obstructive pulmonary disease (COPD). Studies investigating the relationship between health literacy and functional capacity, quality of life, physical activity, cognitive function, health-related behavior, and activities of daily living in individuals with COPD are limited. Therefore, the aim of this study was to compare individuals with COPD with healthy individuals in terms of health literacy, functional capacity, quality of life, physical activity, cognitive function, health-related behavior, and activities of daily living and to investigate the relationship between health literacy and functional capacity, quality of life, physical activity, cognitive function, health-related behavior, and activities of daily living in individuals with COPD.

Participants needed: 144
Trial details
Age: 40+Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Jun 25, 2026Locations: 1
Eligibility criteria

Being over 40 years old, [+4]

Being in an acute exacerbation period, [+6]

Status: Not yet recruiting

Effects of Core-Focused Exercise Training and Kinesiology Taping in Women With Breast Cancer-Related Lymphedema

The aim of the present study is to investigate the effects of trunk- focused exercise training and kinesiology taping, in addition to standard lymphedema treatment (complex decongestive therapy-CDT) on posture, pain, functionality and quality of life in women with breast cancer related lymphedema. This study is designed as a randomized placebo-controlled trial. Lymphedema negatively affects the musculoskeletal system, leading to shoulder girdle muscle imbalances, cervical and thoracolumbar pain, scapular dysfunction and spinal postural alterations. Although CDT is considered the gold standard for edema management, its effects have primarily been evaluated in terms of edema reduction and symptom control, and there is limited evidence regarding its impact on posture, musculoskeletal symptoms, and quality of life, as well as the potential effects of prolonged compression bandaging applied during the intensive phase on these systems. Trunk-focused exercise training is expected to improve spinal stability, mobility and postural control, while kinesiology taping may help alleviate musculoskeletal symptoms by providing proprioceptive input and mechanical support. By combining these interventions, this study aims to provide a comprehensive rehabilitation approach targeting both physical and functional impairments. If additional improvements in posture, pain, function, and quality of life are observed compared to a control group receiving CDT combined with lower extremity exercise and placebo taping, these findings will support the added value of a multimodal rehabilitation approach beyond standard care. The findings of this randomized placebo-controlled trial are expected to contribute to the literature by providing evidence for a comprehensive and holistic treatment approach in breast cancer-related lymphedema and to support the integration of trunk-focused exercise training and kinesiology taping into routine clinical practice. To the best of our knowledge, there is currently no randomized placebo-controlled study investigating the effects of trunk-focused exercise training and kinesiology taping in addition to CDT on posture, pain, functionality, and quality of life.

Participants needed: 46
Trial details
Age: 40-65Biological sex: FemaleType: InterventionalSponsor: Hacettepe UniversityUpdated: Jun 29, 2026Locations: 1
Eligibility criteria

Age between 40 and 65 years [+5]

Body mass index (BMI) >30 kg/m² [+8]

Status: Not yet recruiting

Validation of the Turkish Brief Inventory of Treatment Expectations in Chronic Pain

The purpose of this study is to conduct the Turkish cross-cultural adaptation, validity, and reliability study of the "Brief Inventory of Treatment Expectations in Chronic Pain" (BITEC) scale. Chronic pain is a complex, multidimensional experience that affects a significant portion of the adult population. Treatment expectations play a critical role in predicting clinical outcomes and directly influencing placebo/nocebo responses. While several tools exist to evaluate expectations, there is a lack of a concise, clinician-friendly, and Item Response Theory (IRT)-based instrument adapted for Turkish chronic pain populations. The BITEC is a 9-item scale that evaluates biological, psychological, and social/interactional expectation domains. This methodological and cross-sectional study will be conducted with adult patients diagnosed with chronic pain for at least three months at Bingöl State Hospital. The study will be carried out in four consecutive stages: cross-cultural adaptation (forward and backward translation), comprehensibility pre-testing (with 30-40 volunteers), main data collection (with at least 200 participants), and statistical analyses. Data will be collected through printed forms and an online survey platform (Kobotoolbox), involving no clinical interventions. Participants will complete a sociodemographic information form, the Turkish version of the BITEC (BITEC-TR), the Treatment Expectations in Chronic Pain Scale (TEC-TR), the Pain Catastrophizing Scale (PCS), the Numerical Pain Rating Scale (NPRS), and the Hospital Anxiety and Depression Scale (HADS). Additionally, a subgroup of approximately 60 participants will recomplete the BITEC-TR 7-10 days after the initial session to evaluate test-retest reliability. Psychometric evaluation will include construct validity through exploratory and confirmatory factor analyses, and internal consistency and stability measurements.

Participants needed: 250
Trial details
Age: 18-70Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Jun 29, 2026Locations: 2
Eligibility criteria

Aged 18-70 years [+4]

Presence of cancer-related pain [+3]

Status: Not yet recruiting

Turkish Adaptation of the Pain and Smoking Inventory

The purpose of this study is to perform the Turkish cross-cultural adaptation of the Pain and Smoking Inventory (PSI) and to comprehensively evaluate its reliability, validity, and psychometric properties among daily cigarette smokers with chronic pain.

Participants needed: 200
Trial details
Age: 18-65Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Jun 29, 2026Locations: 2
Eligibility criteria

Aged 18 years and older. [+4]

Having a diagnosis of active psychosis or severe depression. [+5]

Status: Not yet recruiting

Motivational Interviewing in Thoracic Outlet Syndrome

The goal of this clinical trial is to learn if motivational interviewing (MI) works to improve symptoms in people with thoracic outlet syndrome (TOS). TOS is a condition that causes long-term pain, numbness, and weakness in the arm and shoulder area. The main questions it aims to answer are: * Does MI lower pain and improve arm function in people with TOS? * Does psychological resilience predict treatment outcomes in people with TOS? Researchers will compare participants who receive MI sessions plus a home exercise program to those who receive a home exercise program alone. Participants will be randomly assigned to one of the two groups. Participants will: * Follow a home exercise program for 6 weeks * Some participants will also attend up to 4 motivational interviewing sessions * Complete questionnaires about pain, function, sleep, anxiety, and depression at the start and end of the 6-week program

Participants needed: 70
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Jun 25, 2026Locations: 1
Eligibility criteria

Diagnosis of thoracic outlet syndrome [+3]

Accompanying pathologies (cervical disc problems, fibromyalgia, rotator cuff pro... [+1]

Status: Recruiting

Effects of Foot Core Exercises in Patients With Total Hip Arthroplasty

The goal of this clinical trial is to investigate the effects of foot core exercises on lower extremity muscle strength, viscoelastic properties, functional parameters, foot and ankle posture, balance, and the morphological characteristics of periarticular structures of the foot and ankle in individuals with total hip arthroplasty. The main questions it aims to answer are: * Does foot core exercises affect morphological characteristics of the periarticular structures surrounding the foot and ankle? * Does foot core exercises affect viscoelastic properties of the periarticular structures surrounding the foot and ankle? * Does foot core exercises affect lower extremity muscle strength? * Does foot core exercises affect lower extremity functional parameters and balance in individuals with total hip arthroplasty? The researchers will compare the group performing foot core exercises with the group performing routine hip exercises that do not include foot core exercises. Participitants will: * Participants will receive an exercise log after a specialist physiotherapist demonstrates the exercises in practice at the third postoperative mounth. * Visit the clinic every two months from postoperative mounth 3 to month 7 for routine follow-ups and progression of exercises. * Except for the control sessions held every two mounths, patients will be followed up through weekly phone calls. * Participants will complete an exercise diary indicating that they performed the exercises prescribed for each week, and they will bring their diaries with them to the follow-up sessions.

Participants needed: 50
Trial details
Age: 50-80Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Jun 24, 2026Locations: 1
Eligibility criteria

Being between 50 and 80 years old, [+3]

Having undergone revision total hip arthroplasty surgery, [+4]