Investigation of Imagery Abilities in Individuals With Migraine

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorHacettepe University

About this trial

The aim of this study is to compare the motor imagery abilities of patients with migraine to those of healthy individuals, and to examine the relationship between motor imagery and proprioception (cervical and trunk), balance, body awareness, anxiety, and depression levels. Additionally, the study aims to investigate the relationship between proprioception and balance in patients with migraine. Motor imagery abilities of patients with migraine and healthy control subjects (aged 18-65 years; planned sample size: 68 individuals in each group, 68 migraine patients and 68 healthy participants) will be assessed using the Movement Imagery Questionnaire-3, the Motor Imagery Ability Test, mental chronometry, mental rotation tasks, and functional MRI (fMRI) during motor imagery of different tasks. Additionally, in patients with migraine, cervical and trunk proprioception, balance, body awareness, the Tampa Scale for Kinesiophobia, the Vertigo Symptom Scale, the Dizziness Handicap Inventory, and the Hospital Anxiety and Depression Scale will be evaluated.

1. Hypothesis H0: There is no difference in motor imagery abilities between patients with migraine and healthy controls.

H1: There is a difference in motor imagery abilities between patients with migraine and healthy controls. 2. Hypothesis H0: There is no relationship between motor imagery abilities and proprioception in patients with migraine. H1: There is a relationship between motor imagery abilities and proprioception in patients with migraine. 3. Hypothesis H0: There is no relationship between proprioception (cervical/trunk) and balance in patients with migraine.

H1: There is a relationship between proprioception (cervical/trunk) and balance in patients with migraine. 4. Hypothesis H0: There is no relationship between motor imagery abilities and body awareness, anxiety, and depression in patients with migraine.

H1: There is a relationship between motor imagery abilities and body awareness, anxiety, and depression in patients with migraine.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Diagnosed with migraine by a neurologist according to ICHD-3 criteria

Aged 18-65 years

Score greater than 21 on the Montreal Cognitive Assessment (MoCA)

Aged 18-65 years

Disqualifiers

Presence of additional neurological or orthopedic disorders

Current use of psychiatric medications

Severe musculoskeletal, cardiovascular, pulmonary, metabolic, or other medical conditions that would prevent participation in the study

Significant visual or hearing impairments

Trial population

migraine patients

Trial design

Design model

Case-control

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

126 Participants
are grouped into 2 trial groups
Group A: migraine patients
Group B: Healthy Participants

Trial outcomes

Primary outcomes

1

Headache Assessment: Numerical Pain Scale

The numeric pain scale is used to assess the severity of a headache.The pain a person feels is evaluated on a scale from "0: no pain at all" to "10: I feel very severe pain."

Time frame
From August 2026 to January 2027
2

Movement Imagery Questionnaire-3

The Movement Imagery Questionnaire-3 is the most up-to-date version of the Movement Imagery Questionnaire and the Movement Imagery Questionnaire-Revised, Second Edition.The questionnaire consists of 12 items and separately evaluates external, internal, and kinesthetic imagery abilities. After each imagery task, individuals rate their experience on a scale from 1 to 7 (1 - very difficult to feel/see, 7 - very easy to feel/see).

Time frame
From August 2026 to January 2027
3

Motor Imagery Ability Test

The ability to imagine movement is used to test the controllability component of imagery (CC). It is defined as the ability to manipulate, transform, or maintain an imagined body movement over time

Time frame
From August 2026 to January 2027
4

Mental Chronometry

The administration of questionnaires is quite easy and quick. However, the subjectivity arising from individuals rating themselves in these questionnaires should not be overlooked. Mental chronometry can be defined as the time required by the neural system to process information. It is based on a different foundation than the questionnaires mentioned above. Mental chronometry is a parameter that measures the duration of motor imagery and is based on the assumption that the time required to perform a movement is the same as the time needed to imagine it. Compared to questionnaires, mental chronometry is a more objective measure; however, it does not evaluate the clarity or vividness of imagery. Mental chronometry measurements are planned to be carried out using the method described by Oostra et al.

Time frame
From August 2026 to January 2027

Secondary outcomes

1

Cervical Proprioception Assessment

The Cervical Joint Position Sense Test is used to assess cervical position sense. In this test, a laser pointer attached to the participant's head and a board with concentric circles drawn at 1 cm intervals are used. Participants are asked to sit on a chair with back support. The distance between the panel and the participant is set at 90 cm. The laser pointer is aligned with the center of the board. Participants are asked to close their eyes and memorize this central point.

Time frame
from August 2026 to January 2027
2

Trunk Proprioception Assessment

Proprioception measurement is planned using a Dualer IQ Pro Digital Inclinometer with a repositioning test during trunk flexion. A target angle of 30° flexion is used.

Time frame
from August 2026 to January 2027
3

Neck Awareness Assement

The Fremantle Neck Awareness Questionnaire is a 9-item questionnaire that evaluates attention, proprioceptive sensation (body awareness), neglect, and the perception of the neck's shape and size. A higher score on the Fremantle Neck Awareness Questionnaire indicates lower neck awareness.

Time frame
from August 2026 to January 2027
4

Balance Assessment

Balance assessment will be performed using the HUR Smart Balance device on both firm and soft surfaces, with eyes open and closed.

Time frame
from August 2026 to January 2027

Other outcomes

1

Body Awareness Questionnaire

Body Awareness Questionnaire: The Body Awareness Questionnaire was developed by Shields et al., and its Turkish validity and reliability study was conducted by Seda Karaca. It is a questionnaire designed to assess the level of awareness of body composition. Participants are asked to rate each item on a scale from 1 to 7 (1 = not at all true for me, 7 = completely true for me). The total score ranges from a minimum of 18 to a maximum of 126. An increase in the total score indicates a higher level of body awareness.

Time frame
from August 2026 to January 2027
2

The Tampa Scale for Kinesiophobia

The Tampa Scale for Kinesiophobia was used to assess fear of movement (kinesiophobia). The aim of this scale is to distinguish between individuals with normal responses and those with high levels of fear of movement. The scale consists of 17 items and uses a 4-point Likert scoring system. Higher scores indicate greater fear of movement. In studies, the use of the total score is recommended.

Time frame
From August 2026 to January 2027
3

The Vertigo Symptom Scale

The Vertigo Symptom Scale is a subjective questionnaire that measures vertigo, dizziness, and autonomic-anxiety symptoms experienced within the last month. In this study, the 15-item short form will be used. Of the 15 items, 8 are related to vertigo and balance, and 7 are related to autonomic-anxiety symptoms. Each item is scored on a 0-4 scale: never (0 points), very rarely (1 point), sometimes (2 points), often (3 points), and very often (4 points). The total score ranges from 0 to 60, with higher scores indicating more severe impairment. A total score of 12 or above is considered clinically significant.

Time frame
From August 2026 to January 2027
4

The Dizziness Handicap Inventory

The Dizziness Handicap Inventory is a 25-item self-report questionnaire that evaluates the impact of dizziness and vertigo on quality of life. The items are designed to assess functional, physical, and emotional changes.Each question has three response options: yes, sometimes, and no. Responses are scored as 4 points for yes, 2 points for sometimes, and 0 points for no. The maximum possible score is 100. Higher scores indicate more severe dizziness-related disability.

Time frame
From August 2026 to January 2027

Locations

This trial has no locations.

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