About this trial
The aim of this study is to compare the motor imagery abilities of patients with migraine to those of healthy individuals, and to examine the relationship between motor imagery and proprioception (cervical and trunk), balance, body awareness, anxiety, and depression levels. Additionally, the study aims to investigate the relationship between proprioception and balance in patients with migraine. Motor imagery abilities of patients with migraine and healthy control subjects (aged 18-65 years; planned sample size: 68 individuals in each group, 68 migraine patients and 68 healthy participants) will be assessed using the Movement Imagery Questionnaire-3, the Motor Imagery Ability Test, mental chronometry, mental rotation tasks, and functional MRI (fMRI) during motor imagery of different tasks. Additionally, in patients with migraine, cervical and trunk proprioception, balance, body awareness, the Tampa Scale for Kinesiophobia, the Vertigo Symptom Scale, the Dizziness Handicap Inventory, and the Hospital Anxiety and Depression Scale will be evaluated.
1. Hypothesis H0: There is no difference in motor imagery abilities between patients with migraine and healthy controls.
H1: There is a difference in motor imagery abilities between patients with migraine and healthy controls. 2. Hypothesis H0: There is no relationship between motor imagery abilities and proprioception in patients with migraine. H1: There is a relationship between motor imagery abilities and proprioception in patients with migraine. 3. Hypothesis H0: There is no relationship between proprioception (cervical/trunk) and balance in patients with migraine.
H1: There is a relationship between proprioception (cervical/trunk) and balance in patients with migraine. 4. Hypothesis H0: There is no relationship between motor imagery abilities and body awareness, anxiety, and depression in patients with migraine.
H1: There is a relationship between motor imagery abilities and body awareness, anxiety, and depression in patients with migraine.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Diagnosed with migraine by a neurologist according to ICHD-3 criteria
Aged 18-65 years
Score greater than 21 on the Montreal Cognitive Assessment (MoCA)
Aged 18-65 years
Disqualifiers
Presence of additional neurological or orthopedic disorders
Current use of psychiatric medications
Severe musculoskeletal, cardiovascular, pulmonary, metabolic, or other medical conditions that would prevent participation in the study
Significant visual or hearing impairments
Trial population
migraine patients
Trial design
Case-control
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Headache Assessment: Numerical Pain Scale
The numeric pain scale is used to assess the severity of a headache.The pain a person feels is evaluated on a scale from "0: no pain at all" to "10: I feel very severe pain."
Movement Imagery Questionnaire-3
The Movement Imagery Questionnaire-3 is the most up-to-date version of the Movement Imagery Questionnaire and the Movement Imagery Questionnaire-Revised, Second Edition.The questionnaire consists of 12 items and separately evaluates external, internal, and kinesthetic imagery abilities. After each imagery task, individuals rate their experience on a scale from 1 to 7 (1 - very difficult to feel/see, 7 - very easy to feel/see).
Motor Imagery Ability Test
The ability to imagine movement is used to test the controllability component of imagery (CC). It is defined as the ability to manipulate, transform, or maintain an imagined body movement over time
Mental Chronometry
The administration of questionnaires is quite easy and quick. However, the subjectivity arising from individuals rating themselves in these questionnaires should not be overlooked. Mental chronometry can be defined as the time required by the neural system to process information. It is based on a different foundation than the questionnaires mentioned above. Mental chronometry is a parameter that measures the duration of motor imagery and is based on the assumption that the time required to perform a movement is the same as the time needed to imagine it. Compared to questionnaires, mental chronometry is a more objective measure; however, it does not evaluate the clarity or vividness of imagery. Mental chronometry measurements are planned to be carried out using the method described by Oostra et al.
Secondary outcomes
Cervical Proprioception Assessment
The Cervical Joint Position Sense Test is used to assess cervical position sense. In this test, a laser pointer attached to the participant's head and a board with concentric circles drawn at 1 cm intervals are used. Participants are asked to sit on a chair with back support. The distance between the panel and the participant is set at 90 cm. The laser pointer is aligned with the center of the board. Participants are asked to close their eyes and memorize this central point.
Trunk Proprioception Assessment
Proprioception measurement is planned using a Dualer IQ Pro Digital Inclinometer with a repositioning test during trunk flexion. A target angle of 30° flexion is used.
Neck Awareness Assement
The Fremantle Neck Awareness Questionnaire is a 9-item questionnaire that evaluates attention, proprioceptive sensation (body awareness), neglect, and the perception of the neck's shape and size. A higher score on the Fremantle Neck Awareness Questionnaire indicates lower neck awareness.
Balance Assessment
Balance assessment will be performed using the HUR Smart Balance device on both firm and soft surfaces, with eyes open and closed.
Other outcomes
Body Awareness Questionnaire
Body Awareness Questionnaire: The Body Awareness Questionnaire was developed by Shields et al., and its Turkish validity and reliability study was conducted by Seda Karaca. It is a questionnaire designed to assess the level of awareness of body composition. Participants are asked to rate each item on a scale from 1 to 7 (1 = not at all true for me, 7 = completely true for me). The total score ranges from a minimum of 18 to a maximum of 126. An increase in the total score indicates a higher level of body awareness.
The Tampa Scale for Kinesiophobia
The Tampa Scale for Kinesiophobia was used to assess fear of movement (kinesiophobia). The aim of this scale is to distinguish between individuals with normal responses and those with high levels of fear of movement. The scale consists of 17 items and uses a 4-point Likert scoring system. Higher scores indicate greater fear of movement. In studies, the use of the total score is recommended.
The Vertigo Symptom Scale
The Vertigo Symptom Scale is a subjective questionnaire that measures vertigo, dizziness, and autonomic-anxiety symptoms experienced within the last month. In this study, the 15-item short form will be used. Of the 15 items, 8 are related to vertigo and balance, and 7 are related to autonomic-anxiety symptoms. Each item is scored on a 0-4 scale: never (0 points), very rarely (1 point), sometimes (2 points), often (3 points), and very often (4 points). The total score ranges from 0 to 60, with higher scores indicating more severe impairment. A total score of 12 or above is considered clinically significant.
The Dizziness Handicap Inventory
The Dizziness Handicap Inventory is a 25-item self-report questionnaire that evaluates the impact of dizziness and vertigo on quality of life. The items are designed to assess functional, physical, and emotional changes.Each question has three response options: yes, sometimes, and no. Responses are scored as 4 points for yes, 2 points for sometimes, and 0 points for no. The maximum possible score is 100. Higher scores indicate more severe dizziness-related disability.
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