Exercise Performance on Ambient Air vs. Low-Flow Liquid Oxygen Therapy in Pulmonary Vascular Disease (PVD)

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorSilvia Ulrich Somaini

About this trial

The investigators aim to study the effect of liquid oxygen therapy (4l/min, nasal) )in Swiss residents with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH).

Eligibility criteria

Qualifiers

- Minimum 18 years of age

Written informed consent

Patients with diagnosed pulmonary arterial hypertension (PAH), distal chronic thromboembolic pulmonary hypertension (CTEPH), chronic obstructive pulmonary disease (COPD) with emphysema, COPD without emphysema, or interstitial lung disease

Former desaturation under exercise defined as SpO2-decrease >3%

Disqualifiers

- Severe hypoxemia needing supplemental oxygen therapy defined as PaO2 < 6.9 kPa

Inability or contraindications to undergo the investigated intervention

Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, walk disability etc.

Trial design

Treatments tested in this trial

  • 6-minute walk distance (6MWD) test on ambient conditions
  • 6-minute walk distance (6MWD) test with supplemental oxygen (LOX)

Treatment groups

40 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Silvia Ulrich Somaini

Lead sponsor

University of Zurich

Sponsor institution