Exploring Perceptual Learning in Blurred Gabor Discrimination for Low-Myopic Children
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age6-10
SponsorNational Taiwan University Hospital
About this trial
This exploratory study investigates whether perceptual learning using blurred Gabor stimuli can improve uncorrected distance visual acuity in children aged 6-10 years with low myopia. Participants will be randomly assigned to a training group or control group. The training group will undergo individualized visual perceptual learning through a digital Vision Training System (VTS) for approximately 3 months. The study will also evaluate changes in refraction, contrast sensitivity, visual crowding, Chinese reading acuity with eye movements, and sweep visual evoked potentials (sVEPs).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Children aged between 6 to 10 years.
Best corrected distance visual acuity of 6/6 or 0.00 logMAR.
Diagnosed with low myopia after a comprehensive ophthalmologic examination, with a spherical equivalent refractive error ranging from -0.50 to -1.25 diopters, including up to -0.75 diopters of astigmatism.
Atropine (mydriatic agent)
Disqualifiers
Strabismus
Binocular vision problems
Ocular diseases
History of ocular surgery (excluding refractive surgery)
Trial design
Design model
Parallel
Treatments tested in this trial
vision training system, VTS
BehavioralParticipants in this group will receive individualized visual perceptual learning using the Vision Training System (VTS). The training involves blurred Gabor stimuli presented via a computer-based application. Each participant will complete approximately 20 training sessions over 3 months, with each session lasting 15 to 30 minutes, conducted twice per week. The program is designed to enhance uncorrected visual acuity, contrast sensitivity, and other visual functions by engaging neural mechanisms related to perceptual learning. Training progression is adaptive based on individual performance. The VTS software was developed in collaboration with Bar Ilan University.
Treatment groups
30 Participants
are divided into 2 treatment groupsGroup A: Visual Perceptual Learning GroupExperimental treatment 1 intervention
Group B: Control GroupNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Change in Best Corrected Visual Acuity (BCVA) From Baseline
Best Corrected Visual Acuity (BCVA) will be measured using the ETDRS or Snellen chart at a distance of 3 meters under standardized lighting conditions. The change in BCVA from baseline to post-training will be assessed.
Time frame
From enrollment to 12 months after completion of the 3-month training programSecondary outcomes
1
Change in Spherical Equivalent Refraction (Diopters) From Baseline
Spherical equivalent refraction will be measured using both automated and subjective refraction methods. Changes in spherical equivalent diopters will be assessed and compared between groups.
Time frame
From enrollment to 12 months after completion of the 3-month training program2
Change in Contrast Sensitivity Across Spatial Frequencies From Baseline
Contrast sensitivity will be measured using the CSV-1000E test at a distance of 2.5 meters, assessing spatial frequencies at 3, 6, 12, and 18 cycles per degree (cpd). Changes from baseline will be evaluated.
Time frame
From enrollment to 12 months after completion of the 3-month training program3
Change in Visual Crowding Acuity From Baseline
Visual crowding acuity will be assessed using the Freiburg Vision Test (FrACT) before and after the training program. Changes from baseline will be evaluated.
Time frame
From enrollment to 12 months after completion of the 3-month training program4
Change in Reading Visual Acuity and Eye Movement Parameters From Baseline
Reading visual acuity and eye movements will be assessed using a custom Chinese reading test for children. Eye movements will be recorded using a Tobii eye tracker. Measured metrics include critical print size, maximum reading speed, and maximum reading acuity. Changes from baseline will be evaluated.
Time frame
From enrollment to 12 months after completion of the 3-month training programSponsors and contacts
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Source ClinicalTrials.gov
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