Frailty and Outcomes in Older Emergency Department Patients With Pneumonia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age65+
SponsorEge University
About this trial
Pneumonia is one of the leading causes of infection-related mortality in the older population. Traditional severity scores used in emergency departments, such as the Pneumonia Severity Index (PSI) and CURB-65, primarily focus on acute physiological derangements and may not adequately capture biological reserve and frailty in older adults. Frailty is a geriatric syndrome reflecting increased vulnerability to stressors and reduced recovery capacity.
This prospective observational cohort study aims to evaluate the predictive value of the Clinical Frailty Scale (CFS) for in-hospital mortality, 30-day mortality, and morbidity in patients aged 65 years and older presenting to the emergency department with pneumonia. Additionally, the study will assess whether incorporating frailty assessment into existing pneumonia severity scores improves prognostic accuracy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥65 years
Clinical and radiological diagnosis of pneumonia in the emergency department
Ability to obtain informed consent from the patient or legal representative
Availability of a caregiver or relative able to describe baseline functional status
Disqualifiers
Presentation with cardiopulmonary arrest or ongoing cardiopulmonary resuscitation at admission
Confirmed COVID-19 pneumonia
Inability to obtain reliable baseline functional history due to absence of an informant
Refusal to provide informed consent
Trial population
Older adults aged 65 years and above presenting to a tertiary university hospital emergency department with a clinical and radiological diagnosis of pneumonia. The study population represents geriatric patients with acute infectious respiratory illness requiring emergency evaluation, including a wide range of comorbidity and functional status levels typical of real-world emergency department practice.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Clinical frailty scale
Other interventionFrailty assessment performed at emergency department presentation using the 9-point Clinical Frailty Scale.
Clinical Frailty Scale (CFS)
Diagnostic testThe Clinical Frailty Scale (CFS) will be assessed on a 1-9 scale. The CFS score obtained at presentation will also be compared with the patient's baseline CFS prior to the onset of the current illness symptoms.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
In hospital mortality
All-cause mortality occurring during the same hospital admission after emergency department presentation.
Time frame
During index hospitalization (7 and 14 days)Sponsors and contacts
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Source ClinicalTrials.gov