Gender Based Comparison of the Effects of Sensory Modulated Graded Weight Bearing Physiotherapy In Adults With Knee Osteoarthritis

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-60
SponsorShifa Tameer-e-Millat University

About this trial

This comparative experimental study aims to evaluate the effectiveness of Sensory-Modulated Graded Weight-Bearing Physiotherapy (SMGWBP) in patients with knee osteoarthritis and compare treatment outcomes between male and female participants. Participants will receive a 6-week physiotherapy program with assessments conducted at baseline (pre-intervention), mid-intervention (3 weeks), and post-intervention (6 weeks) using validated outcome measures.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age between 40 and 60 years.

Diagnosed with Grade II or Grade III Knee Osteoarthritis according to Kellgren-Lawrence Classification.

Ability to ambulate independently without assistive devices.

Mild to moderate pain intensity with a Visual Analogue Scale score less than seven.

Disqualifiers

History of knee surgery within the previous six months.

Neurological disorders affecting balance, gait, or proprioception.

Severe cardiovascular disease limiting participation in exercise.

Rheumatoid arthritis or other inflammatory arthritic conditions.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Sensory-Modulated Graded Weight-Bearing Physiotherapy

    Behavioral

    A structured six-week Sensory-Modulated Graded Weight-Bearing Physiotherapy Programme consisting of three supervised sessions per week (18 sessions total). Each session includes warm-up, sensory modulation, proprioceptive training, graded weight-bearing strengthening, functional mobility exercises, and cool-down activities. The programme progresses through three phases: Weeks 1-2 focus on sensory activation and proprioceptive training; Weeks 3-4 on graded weight-bearing strengthening; and Weeks 5-6 on functional weight-bearing integration. Exercises are progressed according to participant tolerance, pain severity, and functional performance. Both male and female groups receive the same intervention.

Treatment groups

52 Participants
are divided into 2 treatment groups
Group A: Arm 1 - Arm Title: Male ParticipantsExperimental treatment 1 intervention
Group B: Arm 2 - Arm Title: Female ParticipantsExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in Pain Intensity Measured by the Visual Analog Scale

To evaluate the change in pain intensity following a 6-week Sensory-Modulated Graded Weight Bearing Physiotherapy program in patients with knee osteoarthritis.

Time frame
Baseline, Week 3, and Week 6
2

Change in Physical Function Measured by the Western Ontario and McMaster Universities Osteoarthritis Index

To assess changes in physical function following Sensory-Modulated Graded Weight-Bearing Physiotherapy.

Time frame
Baseline, Week 3, and Week 6
3

Change in Proprioception Measured by the Joint Position Sense (JPS) Test

To assess changes in knee joint proprioception following Sensory Modulated Graded Weight-Bearing Physiotherapy

Time frame
Baseline, Week 3, and Week 6
4

Change in Gait Performance Measured by the Six-Minute Walk Test (6MWT)

To assess changes in gait performance following Sensory Modulated Graded Weight-Bearing Physiotherapy

Time frame
Baseline, Week 3, and Week 6

Secondary outcomes

1

Change in Health-Related Quality of Life Measured by the Short Form-36 (SF-36)

To assess changes in health-related quality of life following Sensory-Modulated Graded Weight-Bearing Physiotherapy

Time frame
Baseline, Week 3, and Week 6
2

Treatment Compliance

To assess participants adherence to the prescribed 6-week Sensory Modulated Graded Weight Bearing Physiotherapy program. Treatment compliance determine based on the percentage of complete supervised treatment session

Time frame
At the end of the 6 week intervention

Other outcomes

Sponsors and contacts

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