The goal of this observational cohort study is to prove whether genetic, epigenetic, transcriptomic, proteomic, metabolomic, imaging, voice, and clinical markers can improve prediction of early complications after cardiac surgery in adult patients.
The main questions it aims to answer are:
Which biological and clinical markers are associated with: new-onset atrial fibrillation (NOAF), acute kidney injury (AKI), postoperative delirium (POD), vasoplegia, postoperative bleeding and 30-day mortality? Can combining these markers improve early prediction of postoperative complications compared with current clinical risk scores?
Researchers will analyze a wide range of data collected before, during, and after cardiac surgery and compare patients who develop early complications with those who do not to identify risk factors and early biomarkers.
Participants will:
Provide biological samples (blood, urine, stool) before and after surgery for genetic, epigenetic, transcriptomic, proteomic, metabolomic, microbiome, and laboratory testing.
Undergo standard preoperative and intraoperative imaging and clinical assessments.
Allow collection of clinical data related to postoperative outcomes (For some participants) have voice and video recordings performed to help identify early signs of postoperative delirium.
This study aims to improve early detection of postoperative complications and support development of personalized diagnostic and treatment strategies for patients undergoing cardiac surgery.
Adults (≥18 years old)
Undergoing elective cardiac surgery
Able and willing to provide informed consent
Age below 18 years
Lack of informed consent
Prior or planned solid organ transplantation
Prior or planned bone marrow transplantation
Adult patients undergoing elective cardiac surgery at a single center. Participants include men and women who consent to provide clinical data and biospecimens for analysis. Individuals under 18 years of age or with prior or planned organ or bone marrow transplantation are excluded.
Cohort
Prospective
Multi-Omics Data and Clinical Data Collection
Other interventionCollection of blood, urine, stool, imaging data, intraoperative data, and non-invasive digital recordings (voice and video) for genetic, epigenetic, transcriptomic, proteomic, metabolomic, microbiome, laboratory, and clinical analyses. No therapeutic intervention is given. All procedures involve observational data and biospecimen collection before, during, and after elective cardiac surgery.
New-onset atrial fibrillation (NOAF)
Occurrence of new-onset atrial fibrillation after cardiac surgery, defined according to current ESC guidelines, using clinical data, ECG and centrally recorded rhythm data.
Acute kidney injury (AKI)
Occurrence of acute kidney injury after cardiac surgery, defined according to KDIGO criteria, using serial laboratory measurements (including serum creatinine and other kidney biomarkers).Early postoperative period after cardiac surgery during index hospitalization.
Postoperative delirium (POD)
Occurrence of postoperative delirium after cardiac surgery, defined according to DSM-V criteria and assessed with validated delirium scales (e.g., CAM-ICU or DOSS), clinical observation, and supporting data (including voice and image recordings in selected patients).
Vasoplegia
Occurrence of vasoplegia after cardiac surgery, identified from perioperative and postoperative hemodynamic and clinical data according to prespecified criteria in the protocol.
In-hospital mortality
Death from any cause occurring during the index hospitalization after cardiac surgery.
30-day mortality
Death from any cause within 30 days after cardiac surgery, assessed through hospital records and follow-up.
Duration of mechanical ventilation
Total duration of postoperative invasive mechanical ventilation, measured in hours, based on clinical and ICU records.
ICU length of stay
Duration of postoperative stay in the intensive care unit, measured in days, based on clinical records.
Click on the lead sponsor to view all of their trials.
Medical University of Gdansk
Lead sponsor
Politechnika Gdańska
Collaborator
University of Gdańsk
Collaborator
Pomeranian Medical University Szczecin
Collaborator
Silesian University of Medicine
Collaborator
AGH University of Science and Technology, Krakow, Poland
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
