Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome

ConditionsCarpal Tunnel Syndrome (CTS)Glucocorticoid Pain Dextrose

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-65

SponsorTanta University

About this trial

This study aims to compare the efficacy and outcomes of perineural injection with 5% dextrose, local ozone and glucocorticoid injection in the management of carpal tunnel syndrome.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults aged 18-65 years with a clinical diagnosis of mild to moderate Carpal Tunnel Syndrome .

Clinical diagnosis of mild to moderate Carpal Tunnel Syndrome , as classified by Bland neurophysiological classification scale: Mild Carpal Tunnel Syndrome : Slow Distal Sensory Latency(≥3.6 ms), Normal Distal Motor Latency(< 4.5 ms)

Moderate Carpal Tunnel Syndrome : Slow Distal Sensory Latency (≥ 3.6 ms), Slow Distal Motor Latency (4.5 - 6.4 ms)

Failure to respond to conservative treatments (e.g., splinting, activity modification, or oral medications) for at least 6 weeks.

Disqualifiers

Patient refusal.

Severe Carpal Tunnel Syndrome requiring surgical intervention, as defined by the Bland neurophysiological classification scale: Severe Carpal Tunnel Syndrome: Absent Distal Sensory Latency and Slow Distal Motor Latency (4.5 - 6.4 ms)

Previous corticosteroid injection for Carpal Tunnel Syndrome within the last 6 months.

History of wrist trauma, surgery or anatomical abnormalities.

Trial design

Design model

Parallel

Treatments tested in this trial

Perineural injection with 5% dextrose (D5W).
Drug
Group 1: Perineural injection with 5% dextrose (D5W).
Local ozone injection
Drug
Group 2: Local ozone injection
Local glucocorticoid injection (dexamethasone).
Drug
Group 3: Local glucocorticoid injection (dexamethasone).

Treatment groups

105 Participants

are divided into 3 treatment groups

Group A: Group 1Experimental treatment 1 intervention

Group B: Group 2Experimental treatment 1 intervention

Group C: Group 3Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

median nerve distal motor latency

Time frame

3 months

Secondary outcomes

Evaluation of analgesic efficacy via assessment of Visual Analog Scale

Time frame

At 1 and 3 months.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Tanta University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: