About this trial
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how growth hormone affects beta-cells and risk factors for developing type 2 diabetes.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
18 to 59 years old
body mass index ≥30.0 kg/m2 and <45.0 kg/m2
Family history of type 2 diabetes: first degree relative with type 2 diabetes
Control group: no family history of type 2 diabetes
Disqualifiers
Pregnant, planning to become pregnant during the study, or breastfeeding
Current diagnosis or history of type 1 or type 2 diabetes
Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
History of bariatric surgery
Trial population
The study population will consist of obese men and women ages 18-45 with and without a first degree relative with type 2 diabetes.
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Beta-cell function
Insulin secretion rate in relationship to plasma glucose
Sponsors and contacts
Click on the lead sponsor to view all of their trials.