Telogen effluvium (TE) is a common cause of diffuse, non-scarring hair shedding in women. It is often triggered by physiological stress, nutritional deficiencies, illness or hormonal changes. There is growing interest in the role of the gut microbiota in hair health, through its effects on nutrient absorption, immune regulation and systemic inflammation (the so-called gut-skin axis). However, data on gut microbiota in women with TE are still scarce.
This retrospective observational study will review the medical records of premenopausal women diagnosed with TE who received a multifactorial drinkable nutraceutical as part of routine clinical care at 2 clinics between January 2025 and July 2025. The study has two aims:
1. To describe the gut microbiota profile of these women at baseline \[and after 6 months\], as assessed by \[stool analysis method\]. 2. To describe changes in trichoscopic parameters, over 6 months of supplementation \[and to explore whether baseline microbiota features are associated with these changes\].
The study does not assign any intervention: all data were collected during standard clinical practice. Its findings are intended to generate hypotheses for future controlled studies.
Women aged 18-40 years.
Premenopausal status.
Diagnosis of telogen effluvium (TE) lasting more than 3 months.
Digestive symptoms with no diagnosed underlying disease (gut microbiota dysbiosis).
Moderate or severe irritable bowel syndrome (IBS).
Small intestinal bacterial overgrowth (SIBO).
Prior use of the study product.
Participation in similar studies or use of anti-hair-loss products within the previous 3 months.
The study population consists of premenopausal women aged 18-40 years with a clinical and trichoscopic diagnosis of telogen effluvium and gut dysbiosis, attended at Clínica AB Derma and Clíncia Hbn39 of Madrid, Spain between January 2025 and July 2025. Eligible women received a multifactorial drinkable nutraceutical for 6 months as part of routine clinical care, and had gut microbiota analysis \[at baseline and at 6 months\] and trichoscopic assessment at baseline and at 6 months recorded in their medical records.
Cohort
Retrospective
Drinkable multifactorial food supplement containing vitamins, minerals, plant extracts, and other bioactive compounds, formulated to support hair growth and scalp health in women.
Dietary supplementDrinkable multifactorial food supplement in liquid form, administered once daily in a 25 mL single-dose vial, for a duration of 180 days. The formulation contains a combination of vitamins, minerals, plant extracts, amino acids, and other bioactive compounds designed to support hair growth and scalp health in women.
Characterization of gut dysbiosis outcomes
Gus dysbiosis was analyzed with a stool kit test (KyberBioma(R)).
Characterization of trichoscopic outcomes
Trychoscopy outcomes were measured using a phototrichoscope at the interparietal area. 7 trichoscopy signs were graded (0-3) from 2 evaluators: telangiectasias, punctate vessels, erythema, scaling, follicular miniaturization, follicular hyperkeratosis, fibrosis.
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