Hemodynamic Responses to Laryngoscopy and Tracheal Intubation

ConditionHemodynamic Response to Laryngoscopy and Tracheal Intubation

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-60

SponsorAssiut University

About this trial

Laryngoscopy and tracheal intubation lead to tachycardia and hypertension due to increase in the plasma catecholamines subsequent to sympathetic stimulation.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients scheduled for elective middle ear surgery under general anesthesia, ASA status I-II, aged from 18 to 60 years old of either sex.

Disqualifiers

Full stomach or emergency surgery

Any known contraindications or allergy to ketamine, dexmedetomidine, or propofol

Pregnancy or breastfeeding women

Body mass index (BMI) > 35 Kg/m2

Trial design

Design model

Parallel

Treatments tested in this trial

ketodex
Drug
Patients will receive a single IV bolus dose of both ketamine and dexmedetomidine
ketofol
Drug
Patients will receive a single IV bolus dose of both ketamine and propofol

Treatment groups

70 Participants

are divided into 2 treatment groups

Group A: KetodexActive comparator 1 intervention

Group B: KetofolPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

Heart rate accompanying laryngoscopy and tracheal intubation with cuff inflation

Assessed in beats per minute

Time frame

The fifth minute after laryngoscopy and tracheal intubation with cuff inflation

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: