The goal of this clinical trial is to evaluate the depth of tissue penetration of Argon Beam Coagulation (ABC) during laparoscopic surgery for ovarian endometriomas. Researchers want to determine how deeply ABC affects ovarian tissue and to generate data on the safety of this surgical technique.
Participants will undergo standard laparoscopic surgery for ovarian endometriomas. During the planned surgical procedure, Argon Beam Coagulation will be applied to the ovarian surface according to the study protocol. The treated tissue will subsequently be excised as part of the planned surgery and analyzed histologically to measure the depth of tissue penetration.
Female patients aged 18-40 years.
Indication for surgical treatment of ovarian endometrioma based on clinical symptoms and/or imaging findings.
Diagnosis of ovarian endometrioma ≥3 cm confirmed by preoperative imaging (ultrasound and/or MRI).
Planned laparoscopic cystectomy.
Expected lack of compliance or inability to understand the study procedures.
Previous surgical procedures on the affected ovary.
Recurrent ovarian endometrioma.
Pregnancy or breastfeeding.
Single group
Argon Plasma Coagulation
Procedure/SurgeryStandardized argon plasma coagulation (APC) is applied to the outer surface of the ovarian endometrioma capsule immediately before laparoscopic cystectomy. The resected tissue is subsequently processed for histological analysis to assess the depth of APC tissue penetration.
Depth of thermal tissue effects in the ovarian endometrioma cyst wall
Histological measurement of the maximum depth of tissue penetration induced by argon plasma coagulation in the ovarian endometrioma capsule after standardized pre-cystectomy application.
Presence of residual endometriotic epithelium
Histological assessment of residual endometriotic epithelium after argon beam coagulation.
Completeness of cyst lining ablation
Histological assessment of the completeness of ablation of the ovarian endometrioma cyst lining after argon beam coagulation.
Thermal damage to adjacent ovarian parenchyma
Histological assessment of thermal damage extending into adjacent ovarian tissue.
Technical success of argon beam application
Feasibility of standardized intraoperative argon beam coagulation, documented as successful completion of the planned procedure.
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