How Can Different Forms of Strengthening Exercises Affect the Muscular Tissue and Its Chemical Markers in Children With Duchenne Muscular Dystrophy

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age6-10
SponsorCairo University

About this trial

The treatment of patients diagnosed with DMD needs to be multidisciplinary, judicious, and always focused on the patient's well-being. Physiotherapy and occupational therapy are very often standard care. Physiotherapy is regarded as crucial for the success of treatment, since it has achieved good results in the short term, such as maintaining the autonomy of these individuals . Physical activity is another method that has been used to treat DMD. Studies have used physical exercise in individuals with DMD in order to decrease muscle deterioration, muscle contractures, and bone fractures, and to increase the time of functional independence

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

DD,

aging from 6 To 10

Disqualifiers

able to understand order

Trial design

Design model

Parallel

Treatments tested in this trial

  • strengthening exercises

    Other intervention

    Concentric strengthening exercises: involves the muscle producing tension and shortening to move a load Isometric strengthening exercises: occurs when a muscle produces tension without a change in muscle length. Isometric contractions involve sarcomere shortening and increasing muscle tension, but do not move a load Eccentric strengthening exercises: occurs when the muscle tension produced is less than the load and a muscle lengthens while under tension

  • Low-Intensity Exercise Protocol

    Other intervention

    The children were trained 3 times per week for 8 weeks on a treadmill without inclination, with speed and time programmed and adapted for this purpose. The length of each training activity was 30 min (Andersen et al. 2013; Markert et al. 2012). The children were acclimated to the treadmill for 7 days before the beginning of the training program, with a speed of 4 m/min, in order to minimize the stress caused by the different environment.

  • traditional physical therapy program

    Other intervention

    traditional physical therapy program to improve strength

Treatment groups

45 Participants
are divided into 3 treatment groups
Group A: Strengthening exercisesExperimental treatment 1 intervention
Group B: Low-Intensity ExerciseExperimental treatment 1 intervention
Group C: Control groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Creatine-kinase (CK)

Time frame
8 weeks
2

Six-minute walk test

Time frame
8 weeks
3

Muscle strength

Time frame
8 weeks

Secondary outcomes

Other outcomes

Sponsors and contacts

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