Health Trials

Hyaluronic Acid and Polynucleotides With Connective Tissue Graft and Coronally Advanced Flap for RT II Gingival Recession

ConditionRT II Gingival Recession
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age15-60
SponsorCairo University

About this trial

This case series will evaluate the effectiveness of injectable hyaluronic acid combined with polynucleotides as an adjunct to coronally advanced flap and connective tissue graft in patients with RT II gingival recession. Twelve patients will be included and followed for 6 months. Clinical outcomes will include percentage of root coverage, clinical attachment level gain, gingival thickness, probing depth, width of keratinized tissue, post-operative pain, and patient aesthetic satisfaction.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with RT II gingival recession.

Age range: 15-60 years.

Systemically healthy patients with no contraindications to surgery.

Patients who have not had previous periodontal surgery in the area of treatment.

Disqualifiers

Periodontitis.

Active systemic disease affecting wound healing.

Pregnancy or breastfeeding.

Improperly aligned teeth or teeth with cervical restorations or crowns.

Trial design

Design model

Single group

Treatments tested in this trial

  • Coronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid/Polynucleotides

    Procedure/Surgery

    A coronally advanced flap will be performed with a de-epithelialized connective tissue graft. Approximately 1-2 mL of a hyaluronic acid and polynucleotide mixture will be applied to the graft before suturing

Treatment groups

12 Participants
are divided into 1 treatment group
Group A: CAF + CTG + Hyaluronic Acid and PolynucleotidesExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Percentage of Root Coverage

Percentage of root coverage will be calculated using the following formula: (Initial Recession Depth - Post-Treatment Recession Depth) / Initial Recession Depth × 100.

Time frame
Baseline, 1 month, 3 months, and 6 months
2

Clinical Attachment Level (CAL) Gain

Clinical attachment level will be measured in millimetres using a UNC-15 periodontal probe

Time frame
Baseline, 3 months, and 6 months

Secondary outcomes

1

Recession Depth

Gingival recession depth will be measured in millimeters using a UNC-15 periodontal probe

Time frame
Baseline, 3 months, and 6 months
2

Recession Width

Gingival recession width will be measured in millimeters using a UNC-15 periodontal probe.

Time frame
Baseline, 3 months, and 6 months
3

Gingival Thickness

Gingival thickness will be measured in millimeters using an endodontic file

Time frame
Baseline, 3 months, and 6 months
4

Probing Depth

Probing depth will be measured in millimeters using a UNC-15 periodontal probe.

Time frame
Baseline, 3 months, and 6 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: