Identification of Genes of Interest for Severe Forms of Preeclampsia

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-45
SponsorUniversity Hospital, Strasbourg, France

About this trial

Preeclampsia is a pregnancy complication characterized by high blood pressure associated with damage to various organs, especially the kidneys. It happens in about 1 to 5% of pregnant women and can cause serious problems for both the mother and the baby.

Several multi-omics studies have already been conducted on preeclampsia, with promising results. However, this is preliminary data that requires further studies. The molecular markers identified in this type of study could potentially be used, first of all, for the early screening of this condition, which is not yet reliably achievable. In addition, the knowledge gained from this research would help us better understand the pathophysiology of preeclampsia. Therefore, the investigators' goal is to carry out a multi-omics analysis of preeclampsia to uncover the genetic and molecular mechanisms involved in this condition.

Eligibility criteria

Qualifiers

Severe hypertension (SBP ≥ 160 mmHg and/or DBP ≥ 110 mmHg) or uncontrolled.

Proteinuria > 3g/24h.

Creatinine ≥ 90 μmol/L.

Oliguria ≤ 500 mL/24h or ≤ 25 mL/h.

Disqualifiers

Diabetes prior to pregnancy

Multiple pregnancy

Long-term medication treatment (except usual pregnancy supplements)

Smoking, alcohol, or drug use during pregnancy

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

100 Participants
are grouped into 2 trial groups

Locations

This trial has no locations