Identify Barriers to Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Newly Diagnosed and Relapsed Acute Leukemia

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorMemorial Sloan Kettering Cancer Center

About this trial

The investigators are doing this research study to assess the percentage of patients receiving stem cell transplantation for the type of blood cancer you have. They want to know how many patients get a transplant and why some patients do get a transplant while others do not. Also they want to explore why some patients elect not to undergo stem cell transplantation, when it is recommended by their physicians.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with newly diagnosed or relapsed acute leukemia. Patients undergoing reinduction due to primary induction failure are also eligible. Patients with acute leukemia will be enrolled to Arm A

Clinically significant cytopenia of at least 2 cell lines affected; Hgb<10,

Platelet<100,000, absolute neutrophil count<1000

Bone marrow blasts >5% and any level of circulating blasts

Disqualifiers

Patients with polycythemia vera (PV) and essential thrombocytosis (ET)

Trial population

Patients with acute leukemia and MDS or MPN who are treated inpatient or outpatient by the Leukemia Service for induction or re-induction therapy (acute leukemia) or initiation of therapy (for MDS or MPN) will be seen by the Adult BMT Service.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • assessments

    Other intervention

    All laboratory assessments performed on this study represent standard of care at our institution. HLA allele typing is performed by the center's HLA laboratory according to standard typing procedures.

Treatment groups

1,365 Participants
are divided into 3 treatment groups
Group A: Patients with Acute Leukemia (Arm A)1 intervention
Group B: Patients with MDS and MPN (Arm B)1 intervention
Group C: Patients with Acute Leukemia or MDS/MPN who Relapse After First Allografts (Arm C)1 intervention

Trial outcomes

Primary outcomes

1

number of patients who proceed to transplant

determine whether an individual patient proceeded to HCT when he or she was considered eligible (based on NCCN guidelines.

Time frame
3 years

Secondary outcomes

Other outcomes

Sponsors and contacts

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