Imaging Measures of Respiratory Health Registry

ConditionsRespiratory Disease Healthy

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age0-99

SponsorUniversity of British Columbia

About this trial

This is a prospective, observational cohort registry that aims to collect data on pulmonary structure and function in healthy people and those with respiratory disease, using structural and functional pulmonary 1H-MRI and hyperpolarized 129Xe-MRI.

Outcome measures generated from MRI may include but are not limited to measures of regional ventilation, pulmonary microarchitecture, and regional gas exchange. Additionally, one of the goals of the registry is to facilitate the development of novel image analysis techniques that have not yet been invented.

These data will be stored along with demographic data, clinical data, and pulmonary function testing (PFT) data.

This is an open registry. Eligible local and international investigators/institutions can apply for access.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Physician-diagnosed lung disease - based on a diagnosis made by a treating staff physician and confirmed by the principal investigator.

Age 0-99 years.

Informed consent by participant, parent, or legal guardian

In the opinion of the Investigator, the participant will likely be able to perform maneuvers to obtain technically acceptable pulmonary XeMRI images.

Disqualifiers

Physical findings at screening that, in the opinion of the Investigator, would compromise the safety of the participant or the quality of the research data.

Requirement of supplementary oxygen to maintain an oxygen saturation above 95%.

Failed MRI screening form.

History of claustrophobia.

Trial population

Eligible individuals with respiratory disease will be identified from various Respiratory Medicine or subspecialty clinics at British Columbia Children's Hospital (BCCH) or from analogous clinics at St Paul's Hospital (SPH). Participants may be contacted using a First Contact Letter, or permission to approach will be obtained by a member of their circle of care. Healthy participants will be recruited from family members of patients in the Division of Respiratory Medicine at BCCH and SPH as well as from the community or other clinics using flyers or a First Contact Letter.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

1H and Xe-129 MRI
Diagnostic test
Traditional 1H-MRI (room air inhalation) and Xe-129 MRI (requires inhalation of Xenon 129 gas).

Treatment groups

1,000 Participants

are divided into 2 treatment groups

Group A: Respiratory Disease1 intervention

Group B: Healthy1 intervention

Trial outcomes

Primary outcomes

Structural proton (1H) MRI data

Includes all proton MRI images collected to assess pulmonary structure. Data may be analysed qualitatively and quantitatively.

Time frame