Impact of Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS) on the Respiratory Physiology in Patients With Prolonged Mechanical Ventilation

ConditionPICS
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20+
SponsorNational Taiwan University Hospital

About this trial

Past research on PICS has mainly focused on the predictability and prognosis of PICS occurrence in ICU patients. Still, there is currently insufficient research on the role of PICS in the care setting of patients who have stabilized and are transferred to respiratory care units such as Respiratory Care Centers (RCCs) for weaning attempts. To understand the impact of PICS on the respiratory physiology of patients undergoing weaning from prolonged mechanical ventilation, investigators propose a one-year research plan

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients are still receiving ventilator support when transferred to the ward where the study is conducted.

Use the respirator continuously for at least 10 days.

Vital signs are stable: blood pressure systolic blood pressure is not lower than 70 mmHg; heartbeat is not lower than 50/min and not higher than 160/min; respiratory rate is not higher than 50/min.

When using respirator support, the oxygen concentration should not exceed 60%.

Disqualifiers

None

Trial population

Potential candidates for screening are adult patients transferred from RCC who are still on ventilators and will undergo screening assessment by researchers.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Impact of Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS) on the Respiratory Physiology in Patients with Prolonged Mechanical Ventilation

To understand whether weaning training strategies for PICS and non-PICS patients may have different considerations when patients undergo spontaneous breathing testing.

Time frame
January 1st,2025 to December 31st,2026

Secondary outcomes

Other outcomes

Sponsors and contacts

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