Impact of Pre-Ablation Prehabilitation on Clinical Outcomes and Cardiorespiratory Fitness in Atrial Fibrillation Patients

ConditionAtrial Fibrillation (AF)

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-70

SponsorNanjing Medical University

About this trial

The primary objective of this study is to compare the effects of a preoperative prehabilitation program versus usual care on post-procedural cardiorespiratory function and clinical outcomes in patients undergoing catheter ablation for atrial fibrillation.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged 18-70 years

Scheduled for first AF ablation

NYHA class I-II

LVEF ≥ 50%

Disqualifiers

Significant structural heart disease (e.g., severe valvular disease)

Contraindications to CPET or exercise training

Cognitive impairment preventing cooperation

Trial design

Design model

Parallel

Treatments tested in this trial

4-week structured prehabilitation program (exercise training + psychological education)
Other intervention
The prehabilitation group will receive a 4-week structured program before ablation, including: Individualized exercise training: Prescription based on cardiopulmonary exercise test results, including aerobic exercise (40%-60% of heart rate reserve) and resistance training Psychological and educational intervention: Structured education based on cognitive behavioral therapy principles, focusing on addressing kinesiophobia Delivery mode: Hybrid (supervised in-hospital sessions + monitored home-based sessions) The usual care group will receive only standard preoperative education without structured rehabilitation.

Treatment groups

100 Participants

are divided into 2 treatment groups

Group A: Prehabilitation GroupExperimental treatment 1 intervention

Group B: Usual Care GroupNo intervention 0 interventions

Trial outcomes

Primary outcomes

Peak Oxygen Uptake at 3 months

Measure: Cardiopulmonary exercise testing

Time frame

3 months post-ablation

Atrial Arrhythmic Events within 90 days

Any atrial arrhythmic events happened within 90 days after the procedure

Time frame

Within 90 days post-ablation

Sponsors and contacts

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Nanjing Medical University

Lead sponsor

The First Affiliated Hospital with Nanjing Medical University

Sponsor institution

Source ClinicalTrials.gov

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