Impact of Smoking on Ultrasound-Guided Infraclavicular Brachial Plexus Block Onset and Duration
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorSelcuk University
About this trial
The present study will be conducted involving 40 patients aged 18-65 years with ASA physical status I and II, scheduled for acute or elective hand or forearm surgery under the lateral infraclavicular block. Patients will be divided into two groups based on smoking status: Group I (non-smokers) and Group II (smokers who smoke ≥20 cigarettes/day for over 1 year).
Using a high-frequency linear ultrasound transducer, the axillary artery, vein, and the three nerve cords will be identified in the lateral infraclavicular region. After disinfection with ethanol-chlorhexidine, a sterile drape will be placed, and the attending anesthesiologist will perform the ultrasound-guided infraclavicular brachial plexus block with a triple injection technique. A total of 10 mL of bupivacaine 0.25% and prilocaine 0.05% will be injected at all three nerve cords.
The primary outcome will be the sensory blockade onset time, while secondary outcomes will include the duration of sensory and motor blockade, motor blockade onset time, time to first postoperative rescue analgesia, and total consumption of rescue analgesia. Postoperative pain will be assessed using the Visual Analogue Scale (VAS) within the first 24 hours at intervals of 2, 4, 8, 12, 16, and 24 hours. If VAS exceeds 30 cm, rescue analgesia with 0.05 mg/kg intravenous morphine sulfate will be administered.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
ASA physical status I and II
Scheduled for acute or elective hand or forearm surgery under the lateral infraclavicular block
Disqualifiers
morbid obesity (body mass index > 40)
bleeding disorder
coagulopathy
medication with vitamin K antagonists
Trial population
Patients aged 18 to 65 years, classified as ASA physical status I and II, scheduled for acute or elective hand or forearm surgery with a lateral infraclavicular block.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
40 Participants
are grouped into 2 trial groupsGroup A: Non-smoker
Group B: Smoker
Trial outcomes
Primary outcomes
1
Sensory blockade onset time
The sensory blockade onset time will be evaluated using a cold ice pack.
Time frame
During procedureSecondary outcomes
1
Duration of sensory blockade
The duration of sensory blockade will be evaluated as the time between the onset of the sensory block and the complete disappearance of the sensory blockade.
Time frame
up to 24 hours2
Duration of motor blockade
The duration of motor blockade will be evaluated as the time between the onset of the motor block and the achievement of Grade 0 on the modified Bromage scale.
Time frame
up to 24 hours3
Motor blockade onset time
The motor blockade onset time will be assessed by movement at the elbow, wrist and fingers using a modified Bromage scale.
Time frame
During procedure4
Time to need for postoperative first rescue analgesia
The Visual Analogue Scale (VAS) \> 3
Time frame
During the postoperative 24-hour period.Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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