Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults

ConditionHealthy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorPurdue University

About this trial

The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota. The soluble fiber in cereal by-products, arabinoxylan (AX), is known to be beneficial for generally promoting gut health. However, it is unclear whether consuming rice bran (RB), the source of AX, is equally helpful or better than consuming the extracted form of AX. This study aims to reveal the potential benefit of insoluble cereal bran fiber ingredients by comparing the effect of soluble arabinoxylan fiber alone and the mostly insoluble rice bran fiber, containing arabinoxylan, on intestinal health and gut microbiota. A placebo (maltodextrin) will be used as a control, with no significant changes expected in this group for the evaluated outcomes.

Participants will:

* Consume two different fiber supplements (soluble arabinoxylan or stabilized rice bran) as well as a placebo (maltodextrin) for 3 weeks each, separated by a 2-week washout period. * Provide blood and stool samples at six different time points. * Complete a food and gastrointestinal symptom diary during the intervention periods.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Men or women.

Aged between 18-45 years.

Body mass index between 18.5 and 25 kg/m².

Able to read/speak English.

Disqualifiers

Gastrointestinal disorders (inflammatory bowel disease, irritable bowel syndrome, gluten sensitivity/intolerance, etc.).

Those who took antibiotics 3 months before the study.

Individuals taking regular medication or supplements that might affect the gut microbiota.

Individuals undertaking weight-loss diets.

Trial design

Design model

Crossover

Treatments tested in this trial

  • Soluble Arabinoxylan

    Dietary supplement

    10 grams of soluble arabinoxylan diluted in 200 mL of water, twice daily for 3 consecutive weeks.

  • Rice Bran

    Dietary supplement

    10 grams of rice bran fiber diluted in 200 mL of water, twice daily for 3 consecutive weeks.

  • Maltodextrin (Placebo)

    Dietary supplement

    10 grams of maltodextrin diluted in 200 mL of water, twice daily for 3 consecutive weeks.

Treatment groups

25 Participants
are divided into 3 treatment groups
Group A: Soluble ArabinoxylanExperimental treatment 1 intervention
Group B: Rice BranExperimental treatment 1 intervention
Group C: MaltodextrinPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Comparison of two test fibers (insoluble cereal bran and soluble arabinoxylan) and a control (maltodextrin) on gut beneficial bacteria

The primary outcome of the study is change in butyrogenic Clostridium cluster XIVa gut bacteria.

Time frame
From enrollment to the end of treatment at 13 weeks.

Secondary outcomes

1

Comparison of two tests (insoluble cereal bran and soluble arabinoxylan) and a control (maltodextrin) on fecal butyrate and intestinal barrier function

Secondary outcomes are fecal butyrate, gut barrier function protein (serum zonulin), and serum lipopolysaccharide-binding protein (LBP)

Time frame
From enrollment to the end of treatment at 13 weeks.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Purdue University

Lead sponsor

Rural Development Administration (RDA) of the Republic of Korea

Collaborator

This trial is not recruiting at the moment. You can still explore other options: