Improve Muscle Weakness in Patient With COPD
ConditionEmphysema or COPD
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50-70
SponsorAl-Zaytoonah University of Jordan
About this trial
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD). The study aimed to determine whether adding BFR to aerobic exercise could enhance muscle strength and functional capacity compared with conventional training alone. The findings demonstrated that aerobic exercise combined with BFR significantly improved lower-limb muscle strength, exercise tolerance, and functional performance in patients with emphysematous COPD. These results suggest that BFR-assisted aerobic training may serve as an effective and safe rehabilitation strategy to improve physical function and quality of life in this population.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients diagnosed with emphysematous chronic obstructive pulmonary disease (COPD).
Clinically stable COPD patients with no acute exacerbation within the previous 4-6 weeks.
Mild to moderate disease severity according to GOLD criteria.
Ability to participate safely in aerobic exercise training.
Disqualifiers
Acute COPD exacerbation or respiratory infection during the study period.
Severe cardiovascular diseases (e.g., unstable angina, uncontrolled hypertension, recent myocardial infarction).
Peripheral vascular disease or contraindications to blood flow restriction (BFR) training.
Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise performance.
Trial design
Design model
Parallel
Treatments tested in this trial
Aerobic Exercise Combined with Blood Flow Restriction
Other interventionAerobic exercise combined with blood flow restriction (BFR) is a rehabilitation technique in which patients perform low- to moderate-intensity aerobic exercise, such as treadmill or cycling training, while a specialized cuff is applied around the proximal part of the limb to partially restrict blood flow. This method aims to enhance muscle strength and functional performance using lower exercise intensity, making it suitable for patients with limited exercise tolerance, such as individuals with COPD.
Aerobic exercise
Other interventionThe control group performed conventional aerobic exercise training at low to moderate intensity without the application of blood flow restriction. The program included activities such as treadmill walking or cycling to improve cardiovascular endurance, functional capacity, and overall physical fitness in patients with COPD.
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: experimental groupExperimental treatment 1 intervention
Group B: control groupExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
muscle strength
quadriceps strength by isokinetic: Quadriceps strength will be measured using an isokinetic dynamometer at an angular velocity of 60°/s. Participants will perform three to five maximal concentric knee extension efforts after familiarization. Peak torque (Nm) will be recorded, and the highest value will be used for statistical analysis
Time frame
8 weeksSecondary outcomes
1
function capacity
Functional capacity will be assessed using the 1-Minute Sit-to-Stand Test (1STS). Participants will be instructed to sit and stand from a standard chair as many times as possible within one minute without using their upper limbs for assistance. The total number of completed repetitions will be recorded, with higher scores indicating better functional capacity.
Time frame
8 weeksLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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