Health TrialsbyHealthPanel

In Vitro Maturation of Human Eggs

ConditionsHealthyPCOSPCOS (Polycystic Ovary Syndrome)Ovarian ReserveInfertilityInfertility FemaleInfertility of Tubal OriginInfertility Poly Cystic OvaryAMHIn Vitro MaturationIVMIVF
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
AgeUp to 38
SponsorColorado Center for Reproductive Medicine

About this trial

CCRM Fertility, a global pioneer in fertility treatment, research and science, is seeking participants for a new study on in vitro maturation (IVM). IVM requires less hormones to stimulate the ovaries than IVF, making it more affordable than IVF with fewer side effects. Participants that qualify for the study will receive a free cycle of IVM treatment at CCRM Fertility and including a new patient consultation, fertility testing, preimplantation genetic testing for aneuploidies (PGT-A), anesthesia and some medication

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Infertile women diagnosed with PCOS or polycystic ovaries, or infertile women with good ovarian reserve

Antral follicle count (AFC) greater than 24

AMH greater than 3.5 ng/ml

Body Mass Index less than 35

Disqualifiers

More than 2 failed IVF cycles

Trial design

Design model

Single group

Treatments tested in this trial

  • IVM

    Other intervention

    Immature oocytes will be retrieved from small ovarian follicles and matured overnight in the laboratory prior to undergoing fertilization and embryo culture.

Treatment groups

50 Participants
are divided into 1 treatment group
Group A: Biphasic IVM TreatmentExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Oocyte maturation

Maturation rate of retrieved oocytes

Time frame
27 hours
2

Embryo fertilization and development

Number of embryos that fertilize and develop after ICSI. Blastocysts will be biopsied and frozen on days 5, 6, and 7 of development

Time frame
7 days
3

Pregnancy

Pregnancy following embryo transfer. HCG levels and ultrasound confirming IUP and heartrate.

Time frame
6 months

Secondary outcomes

1

Live Birth

Birth information (sex of infant, status, weight, and any complications) will be collected via patient contact when possible.

Time frame
12 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Colorado Center for Reproductive Medicine

Lead sponsor

Source ClinicalTrials.gov
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