About this trial
Respiratory complications are the largest group of complications following anatomical lung resections. Most of these complications result from a disrupted evacuation of respiratory secretions. At present, prevention of such complications involve: aspirating of secretions with a catheter during surgery through an intubation tube, active postoperative rehabilitation, mucolytic treatment and effective postoperative pain management. Suctioning of secretions by a catheter through an intubation tube does not, however, allow for removal of secretions from entire bronchial tree. Bronchofiberoscopy with a small-diameter flexible bronchoscope and thorough, systematic aspiration of secretions from respiratory tract immediately after surgery could presumably result in more effective bronchial cleansing and reduce risk of respiratory complications after surgery. Although the British Thoracic Society guidelines do not recommend routine bronchoscopy as a standard postoperative management after lung resections, they are based on a single, randomized, study analyzing a small group of patients. Bronchoscopy with systematic aspiration of secretions done with a thin flexible scope is a safe procedure, without risk of complications. It does not cause any additional discomfort to the patients and allows for much more accurate aspiration of the bronchial secretions than with a catheter inserted blindly through an intubation tube. It also gives an opportunity to directly evaluate segmental and subsegmental bronchial patency. This is particularly important in patients with COPD who tend to accumulate large amounts of mucus secretion in the bronchial tree.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Pulmonary lobectomy.
Patients must be informed and must sign and give written informed consent.
Disqualifiers
Wedge resection, segmentectomy, pneumonectomy.
Trial design
Parallel
Treatments tested in this trial
Postoperative systematic bronchial aspiration.
Procedure/SurgeryPostoperative flexible bronchoscopy and systematic bronchial aspiration.
Treatment groups
Trial outcomes
Primary outcomes
Atelectasis.
Occurrence of atelectasis on chest X-ray.
Secondary outcomes
Bronchial Secretion Retention Related Complications Score (BRCS).
BRCS will reflect a spectrum of complications resulting from retention of bronchial secretions. Each of the complication will be assigned a number in ordinal scale corresponding to severity of a complication, as follows: 1. Normal breath sounds on auscultation, no atelectasis on CXR, no pneumonia. 2. Residual secretions on auscultation, no atelectasis on CXR, no pneumonia. 3. Atelectasis on CXR, no pneumonia. 4. Pneumonia.
Atrial fibrillation.
Occurrence of new atrial fibrillation on physical examination confirmed by electrocardiography.
CRP.
Serum C-reactive protein level
Sponsors and contacts
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