Influence of Sealer Composition on Post-Endodontic Pain
ConditionPost Endodontic Pain
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorMinia University
About this trial
Postoperative pain (PP) is one of the most common and clinically significant complications following endodontic therapy, occurring shortly after treatment and potentially lasting from a few hours to several days, thereby compromising the patient's quality of life.
The incidence of PP varies widely in the literature, ranging from 1.7% to 70%, with some studies reporting values up to 80% within the first 24 hours, gradually decreasing over a week.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients requiring primary root canal treatment.
Patients with acute irreversible pulpitis.
Patients in good general health
Disqualifiers
Patients with systemic diseases affecting pain perception or healing.
Patients who had taken analgesics or antibiotics within 12-24 hours prior to treatment.
Pregnant or lactating women.
Previously treated teeth or teeth with root resorption, fractures, or severe periodontal disease
Trial design
Design model
Parallel
Treatments tested in this trial
Calcium Hydroxide-based Sealer
Procedure/Surgeryto evaluate and compare the incidence and intensity of postoperative pain following single-visit root canal treatment using three different root canal sealers-calcium hydroxide-based, calcium silicate-based (bioceramic), and epoxy resin-based sealers-in patients with single-rooted teeth, in order to determine the effect of sealer type on patient comfort and analgesic consumption.
Treatment groups
66 Participants
are divided into 3 treatment groupsGroup A: Group A (Calcium Hydroxide-based Sealer: Sealapex):Active comparator 1 intervention
Group B: Group B (Bioceramic Sealer: Well-Root):Active comparator 1 intervention
Group C: Group C (Resin-based Sealer: ADSEAL):Active comparator 1 intervention
Trial outcomes
Primary outcomes
1
Post Endodontic Pain Intensity
Postoperative pain will be assessed using a 10-cm Visual Analog Scale (VAS), where 0 will indicate "no pain" and 10 will indicate "worst imaginable pain." Participants will be instructed to record their pain intensity at 6, 12, 24, 48, and 72 hours, and on the 7th day after treatment. All recorded pain scores will be collected for statistical analysis and comparison among the study groups
Time frame
7 daysSponsors and contacts
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Source ClinicalTrials.gov