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Integrating Aerobic, Respiratory, and Cognitive Training in Acute Heart Failure

ConditionAcute Heart Failure
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age50-65
SponsorCairo University

About this trial

The purpose of this study is to investigate the impact of integrating aerobic, respiratory and cognitive training in acute heart failure.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age between 50-65 years.

All patients are male.

Diagnosed with acute heart failure according to ESC guidelines.

Hemodynamically stable for at least 24 hours.

Disqualifiers

Unstable angina or recent myocardial infarction (< 4 weeks).

Severe uncontrolled arrhythmias or advanced atrioventricular block.

Severe pulmonary disease (e.g., advanced COPD, restrictive lung disease).

Neurological disorders causing cognitive or motor disability.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Aerobic training

    Other intervention

    Participants in the experimental group will receive arm ergometer training performed at the bedside for 10-15 minutes, twice daily, at low-to-moderate intensity corresponding to 40-50% of the age-predicted maximum heart rate, under appropriate monitoring. The intervention will be continued throughout the hospitalization period for a minimum duration of three weeks.

  • Inspiratory muscle training

    Other intervention

    Participants in the experimental group will receive inspiratory muscle training using a threshold device set at 30% of maximal inspiratory pressure, performed twice daily for 15 minutes per session. The training load will be progressively increased according to patient tolerance, and the intervention will be continued throughout the hospitalization period for a minimum duration of three weeks.

  • Cognitive training

    Other intervention

    Participants in the experimental group will receive computerized cognitive training consisting of 20-minute daily sessions targeting attention, memory, and problem-solving abilities. The intervention will be implemented throughout the hospitalization period and will continue for a minimum duration of three weeks.

  • Conventional therapy

    Other intervention

    Participants in both groups will receive conventional therapy. The intervention will be implemented throughout the hospitalization period and will continue for a minimum duration of three weeks.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: Aerobic training + Inspiratory muscle training + Cognitive training + Conventional therapyExperimental treatment 4 interventions
Group B: Conventional therapyActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Functional Exercise Capacity

Functional exercise capacity will be assessed using the Six-Minute Walk Test (6MWT), a standardized submaximal exercise test that measures the total distance walked on a flat surface within six minutes. The 6MWT reflects the integrated performance of the cardiovascular, respiratory, and musculoskeletal systems and is a clinically meaningful indicator of functional status in patients with acute heart failure.

Time frame
3 weeks
2

Peak Oxygen Consumption

Peak oxygen consumption (VO₂ peak) will be estimated using the validated prediction equation developed by Vanhelst et al., which incorporates six-minute walk distance and body mass index. This method provides an indirect assessment of aerobic capacity and cardiorespiratory fitness in patients who are unable to perform maximal exercise testing during hospitalization.

Time frame
3 weeks
3

Inspiratory Muscle Strength

Inspiratory muscle strength will be evaluated by measuring maximal inspiratory pressure (MIP or PImax) using a calibrated manometer. This measurement quantifies the maximum static inspiratory pressure generated against an occluded airway and reflects the functional capacity of the inspiratory muscles.

Time frame
3 weeks
4

Expiratory Muscle Strength

Expiratory muscle strength will be assessed by measuring maximal expiratory pressure (MEP or PEmax) using a standardized manometer. MEP represents the maximal static pressure produced during forced expiration against an occluded airway and provides an objective measure of global expiratory muscle function.

Time frame
3 weeks

Secondary outcomes

1

cardiac troponins

Cardiac troponin levels will be measured as a biomarker of myocardial injury to identify coexisting or precipitating cardiac events and to monitor patient safety during the intervention period.

Time frame
3 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: