Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension
ConditionPostinduction Hypotension
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50+
SponsorCairo University
About this trial
The aim of this work is to assess the efficacy of intermittent ephedrine boluses in prophylaxis against postinduction hypotension in high-risk patients undergoing major abdominal surgery, compared to standard care.
Eligibility criteria
Qualifiers
Adult patients aged >50 years,
weight >50 kg,
American Society of Anesthesiologists (ASA) Physical Status score of > I,
undergoing major abdominal surgery
Disqualifiers
Severe cardiac morbidities (impaired contractility with ejection fraction < 40%, heart block, significant uncontrolled arrhythmias, tight stenotic valvular lesions)
Acute cardiovascular pathologies: acute/decompensated heart failure, acute coronary syndrome
Uncontrolled hypertension (systolic blood pressure>150 mmHg)
Preoperative HR more than 110 bpm despite proper fluid management and patients with renal impairment
Trial design
Treatments tested in this trial
- Normal Saline
- Ephedrine
Treatment groups
124 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov