Intramuscular Temperature on the Echo-textural Characteristics
ConditionHealthy Subjects
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorCardenal Herrera University
About this trial
Echointensity and echotexture have been used as a physiological marker for changes in skeletal muscle quality and structure caused by physical training, low activity, ageing and some neuromuscular disorders. However, there are some influencing factors on muscle echo-intensity and echotexture, such as temperature, which may not be taken into account when performing an ultrasound assessment and may alter the results.
This study aims to investigate the effects of muscle temperature on echointensity and other 2nd order echotextures variables such as homogeneity, contrast, correlation and entropy of muscle tissue, in order to gain a better understanding of this correlation and minimise its influence, which would allow greater precision in the use of muscle ultrasound as a diagnostic tool.
The methodology of this study includes firstly the acquisition of ultrasound images of the vastus lateralis muscle. This acquisition will be performed during the continuous recording of muscle temperature, carried out during a passive cooling process after 20 min of heating using microwave equipment. In addition, to standardise the results, a correction factor will be calculated to compensate for the influence of subcutaneous adipose tissue thickness on echogenicity and echotexture.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Acceptance of participation in the study.
Healthy subjects.
Subjects between the ages of 18 and 65.
Disqualifiers
Have known neurological, cardiovascular, metabolic or orthopedic conditions that prevent them from participating in the study.
Present metal implants in the heating area.
Wear a pacemaker.
Perform physical activity during the 48 hours prior to data collection.
Trial design
Design model
Single group
Treatments tested in this trial
Muscle warm-up
DevicePassive heating of the vastus lateralis of the right quadriceps will be performed using a microwave device. The device will be set at a power of 150 W and a distance of 10-15 cm from the skin surface for 20 minutes with the purpose of increasing local muscle temperature to 40 ºC.
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Muscle temperatureExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Muscle echointensity (0-255 a.u.).
Muscle echointensity is calculated by the mean gray level value of the muscle Range of Interest (ROI). (0-255 a.u.)
Time frame
During intervention2
Muscle echovariance (0-255 a.u.).
The echovariance is determined by the relationship between the standard deviation and the average pixel intensity obtained from the histogram of the muscle ROI. (0-255 a.u.)
Time frame
During intervention3
Muscle energy or second angular momentum.
It is a second order parameter (GLCM) that measures textural uniformity of the muscle ROI
Time frame
During intervention4
Muscle homogeneity.
It is a second-order parameter (GLCM) that measures the uniformity of the muscle ROI composition.
Time frame
During interventionSecondary outcomes
1
Age (years)
Subject's age (years)
Time frame
Pre-intervention2
Sex (female or male)
Subject's sex (female or male)
Time frame
Pre-intervention3
Dominance
Dominant leg (right-left)
Time frame
Pre-intervention4
Body mass index
It is a measure of body fat based on height and weight that applies to adult men and women
Time frame
Pre-interventionSponsors and contacts
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Source ClinicalTrials.gov