Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain
ConditionProcedural Pain
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorHayatabad Medical Complex
About this trial
Propofol is a commonly used intravenous anesthetic agent, but its administration is frequently associated with injection pain, causing patient discomfort and agitation. Various pharmacological agents have been used to reduce this pain, including nalbuphine and lidocaine; however, results from previous studies remain conflicting. This randomized clinical trial aims to compare the effectiveness of intravenous nalbuphine versus intravenous lidocaine in reducing the frequency of propofol-induced injection pain in patients undergoing elective general surgery procedures.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 18-60 years
Either male or female
ASA physical status I or II
Scheduled for elective general surgery under general anesthesia using propofol
Disqualifiers
Known hypersensitivity to propofol, nalbuphine, or lidocaine
Emergency surgery
Use of analgesics prior to surgery
Pregnant women
Trial design
Design model
Parallel
Treatments tested in this trial
Nalbuphine
DrugIntravenous nalbuphine 0.1mg/kg administred 60second prior to induction with propofol
Lidocaine
DrugIntravenous lidocaine 4.5mg/kg (maximum 300mg) administred 60sec prior to induction with propofol
Treatment groups
92 Participants
are divided into 2 treatment groupsGroup A: Nalbupine groupExperimental treatment 1 intervention
Group B: Lidocaine groupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Frequency of propofol- induced injection pain
Presence of injection pain assessed using a four-point pain scale during propofol injection until loss of eyelash reflex. Pain score ≥1 will be considered as presence of injection pain.
Time frame
During induction of anesthesia (within 1-2 minutes of propofol administrationLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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