About this trial
This study aims to investigate the postprandial (2h) and longer term (4 week) effects of a haskap berry supplement on cognitive, vascular, and metabolic function in healthy ageing adults aged 50+.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
50+ years old
Fruit & veg intake less than or equal to 4 servings per day
Adequate English language and visual & auditory acuity to perform the cognitive tasks
Normal BMI for age
Disqualifiers
Being diagnosed with psychological or psychiatric disorders
ADHD or dyslexia
Any food allergy or intolerance
Use of medications and dietary supplements that may impact study results
Trial design
Parallel
Treatments tested in this trial
Placebo
Dietary supplement6g serving of a calorie-matched powder, artificially coloured and flavoured to resemble berry powder
Pure haskap berry powder
Dietary supplement6g serving of a pure, freeze-dried haskap berry powder
Vitamin-and mineral-enhanced haskap berry powder
Dietary supplement6g serving of a vitamin- and mineral-enhanced haskap berry powder (fortified with potassium iodide, zinc bisglycinate, vitamin B5, and vitamin B12
Treatment groups
Trial outcomes
Primary outcomes
Delayed recall (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.
Delayed recall (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.
Delayed recall (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.
Secondary outcomes
Rate of learning (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.
Rate of learning (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.
Rate of learning (Rey Auditory Verbal Learning Task)
The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.
Word recognition (Rey Auditory Verbal Learning Task)
Following the delayed word recall, words from list A, list B and novel words are displayed sequentially on the screen and participants are asked to indicate which words were from list A only.
Other outcomes
IQ (Raven's Progressive Matrices)
The Raven's is a non-verbal intelligence test designed to assess abstract reasoning and fluid intelligence which provides a single score (the sum of correct answers). Ravens will be included in the present study at baseline as a measure of IQ, which may later be utilised as a covariate when analysing the cognitive data.
Habitual diet (Epic-Norfolk Food Frequency Questionnaire)
The FFQ is a validated tool for gauging the average habitual dietary intake of micro and macronutrients of an individual in the UK. Data will be processed using the FETA software.
Sponsors and contacts
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University of Reading
Lead sponsor
Haskapa Ltd
Collaborator