Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-64
SponsorMarquette University
About this trial
Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
Age 18-25 years OR age 40-64 years
Current or former collegiate varsity athlete OR non-athlete control
Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function
Pregnancy
Trial population
Current and former collegiate varsity athletes with and without a prior history of traumatic knee injury and matched non-athlete controls.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
450 Participants
are grouped into 5 trial groupsGroup A: Midlife former athletes with a prior knee injury
Group B: Midlife former athletes without a prior major lower extremity injury
Group C: Midlife controls
Group D: Young adult athletes
Group E: Young adult controls
Trial outcomes
Primary outcomes
1
30-Second Chair Stand Test (primary outcome for Aim 1)
Physical function (functional performance) will be evaluated using the 30-Second Chair Stand Test, 6-Minute Walk Test, and Stair Climb Test. The 30-Second Chair Stand Test uses a standard height chair and requires the participant to stand up and sit down as many times as possible in 30 seconds. More completions indicate better physical function.
Time frame
Baseline2
Sedentary Behavior (primary outcome for Aim 2)
Physical activity will be monitored continuously using an accelerometer worn for 2 weeks. Physical activity will be classified throughout the day as sedentary, light, moderate, or vigorous using established algorithms. The primary outcome for aim 2 is the mean percentage of waking hours in sedentary behavior.
Time frame
BaselineSecondary outcomes
1
Strength
Isometric quadriceps and hamstring strength will be assessed using a standardized strength testing machine (i.e., electromechanical dynamometer).
Time frame
Baseline2
Body Composition
Body composition (i.e., percent body fat) will be assessed via dual-energy x-ray absorptiometry (DXA).
Time frame
Baseline3
Step Counts
Average daily step counts will also be recorded using an objective physical activity monitor.
Time frame
Baseline4
Cardiovascular Disease Risk
The American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease Risk Estimator will be used in the midlife participants to estimate 10-year cardiovascular disease risk.
Time frame
BaselineSponsors and contacts
Click on the lead sponsor to view all of their trials.
Marquette University
Lead sponsor
National Institutes of Health (NIH)
Collaborator
Source ClinicalTrials.gov