About this trial
This study evaluates whether injecting a local anesthetic mixture (ropivacaine, morphine, ketorolac, and epinephrine) under the skin at the incision site before wound closure reduces pain after orthopedic wide excision surgery for bone or soft tissue tumors. Participants will be randomly assigned to receive either the local anesthetic mixture or a saline control injection. Neither participants nor the study team assessing outcomes will know which treatment was given. The main goal is to determine whether this injection reduces the amount of opioid pain medication needed during the first 24 hours after surgery. The study will also assess pain scores, nausea and vomiting, and quality of recovery.
Eligibility criteria
Qualifiers
Scheduled to undergo elective orthopedic wide excision surgery under general anesthesia
American Society of Anesthesiologists (ASA) Physical Status Classification 1, 2, or 3
Age 19 years or older
Disqualifiers
Unwilling to provide informed consent
History of allergy to local anesthetics
History of chronic pain
Use of opioid analgesics within 24 hours before surgery
Trial design
Treatments tested in this trial
- Ropivacaine-Morphine-Ketorolac-Epinephrine-Cefuroxime Mixture
- Cefuroxime-Saline Mixture