This observational study aims to better understand inflammation inside the dental pulp (the inner tissue of the tooth) in patients with symptomatic pulpitis compared with healthy individuals.
Researchers will measure inflammation-related biomarkers in saliva, gingival fluid, and dental pulp samples to determine whether these substances reflect the level of inflammation.
The study also evaluates whether saliva and oral fluids could be used as simple, non-invasive tools to detect and monitor pulp inflammation.
We hypothesize that patients with pulpitis will show different biomarker levels compared with healthy controls.
Age ≥ 18 years, male or female.
Patient consulting for symptomatic pulpitis (confirmed clinical and radiographic diagnosis) or for wisdom tooth extraction (healthy subject).
Patient able to understand the research and having signed a written consent form.
Permanent teeth only.
Refusal to participate.
Pregnancy or breastfeeding.
Antibiotic or anti-inflammatory treatment in the week prior to sampling.
Clinically diagnosed inflammatory gingival or periodontal disease (gingivitis or periodontitis)
Patients consulting at the dental clinic of Nantes University Hospital.
Cohort
Prospective
Not listed
Measurement Compare LXA4 and RvE1 levels in saliva, gingival crevicular fluid, and dental pulp in patients with dental pulpitis and healthy subjects.
Average concentration of LXA4 and RvE1 (expressed in pg/mL or ng/mL) measured by mass spectrometry in each type of biological sample, compared between the pulpitis group and the healthy group.
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Université de Nantes
Lead sponsor
Nantes University Hospital
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
